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Following the large multi-centre multi-country TRAC II study on triple ACTs (TACTs) to treat multi-drug resistant falciparum malaria, DeTACT, a large project funded by DFID, will expand the evaluation of TACTs to African countries and aims to have 2 different TACTs ready for deployment by the end of the project.

The Malaria & Critical Illness Department’s future vision includes work in:

  • Develop fixed dose triple ACTs (TACT) for treating multidrug resistant falciparum malaria
  • Understanding the biology of artemisinin and partner drug resistant falciparum malaria
  • Effects of drug resistance on gametocyte production and transmissibility
  • Transcriptomic changes and biological correlates in multidrug resistant P. falciparum
  • The spread and genetic epidemiology of multidrug resistant P. falciparum
  • Testing new antimalarial compounds
  • Role of malaria vaccines in malaria elimination in Southeast Asia
  • Role of ivermectin in malaria elimination
  • Forest worker malaria prophylaxis
  • Improving housing in hot humid regions to reduce vector entry and prevent malaria
  • Molecular epidemiology and phenotypes of PfHRP2/3 and PfLDH deleted P. falciparum in relation to their detection with rapid diagnostic tests
  • Testing Highly Sensitive (HS)-RDTs to guide FSAT / MSAT approaches for malaria elimination
  • Paracetamol as reno-protective therapy in African children with severe falciparum malaria
  • The free haemoglobin-oxidative stress-AKI pathway in severe malaria
  • The role of the gut microbioma in severe malaria
  • Fluid management in severe falciparum malaria
  • Optimising radical treatment of vivax malaria with primaquine: adapting current dosing recommendations to develop optimised weight and age-based dosing regimens of primaquine
  • Developing innovative primaquine regimens for different regions to obviate the need to test for G6PD deficiency
  • CYP2D6 genetic variants and their impact on primaquine efficacy
  • Plasmodium vivax Controlled Human Infection Models (with HVCTU)
  • Studies on the roll out of the radical cure for P. vivax at village and health post level.
  • Understanding the contributors to intensive care performance in LMICs
  • Developing sustainable training models to improve ICU care in LMICs
  • Developing and implementing setting adapted ICU registries in LMICs
  • The role of lung ultrasound in ICU in LMICs
  • Probiotics to prevent ventilator associated pneumonia in LMICs
  • Optimising mechanical ventilation strategies in LMICs
  • Translating ICU guidelines developed in HIC to LMIC settings