Led by Prof Joel Tarning, Clinical Pharmacology conducts its own research and supports the MORU Tropical Health Network and external research groups with study design, drug measurements, pharmacometric analysis and interpretation of pharmacological results.
Clinical Pharmacology is led by Professor Joel Tarning.
Dr Richard Hoglund leads the Pharmacometrics team. The pharmacometric research group was established in 2007, focusing on pharmacokinetic and pharmacodynamic modelling to further our understanding of infectious disease pharmacology and the optimal use of therapeutic agents. The Pharmacometrics group conducts non-compartmental analysis, nonlinear mixed-effects modelling and optimal study design evaluations. This research has already had a major influence on the currently recommended treatment regimens for malaria.
Dr Urairat Koesukwiwa leads the Routine Laboratory work, focusing on accurate and sensitive LC-MS drug measurements in clinical trial samples. The laboratory has full ISO accreditation for competency (ISO 15189) and safety (ISO 15190) and all assays are conducted to international regulatory guidelines. A particular focus of the drug measurement work is the application of high-throughput filter paper methodologies to facilitate and enable pharmacokinetic field studies.
Professor Joel Tarning leads the Biochemistry & Discovery team, focusing on omics-based research (metabolomics/proteomics/lipidomics), drug measurement, methodology development and medicine quality research. The team develop novel LC-MS methods to quantify drugs in biological samples, with a particular focus on filter paper methodologies to facilitate and enable pharmacokinetic field studies. The metabolomic, proteomic and lipidomic research use in vitro and clinical patient samples in combination with high-resolution/high-accuracy LC-MS measurements to characterise and identify unknown metabolites, develop improved diagnostics, understand pathophysiology, and describe mechanisms of drug action and resistance. The medicine quality research use LC-MS techniques and handheld analytical devices to develop novel methodologies to detect substandard and falsified medicine.
In addition, the MORU Clinical Pharmacology Department has an active, successful postgraduate student programme. If you are interested in doing a postgraduate degree with us, have a look at MORU’s Students page. Then, contact one of our principal investigators for a potential supervisor or Prof Stuart Blacksell, Post-Graduate Student Coordinator.