Dr James Watson
Primaquine and vivax malaria
Primaquine is a drug used to eliminate vivax malaria from the liver and prevent relapses. However, it causes anaemia in patients with G6PD deficiency. A new, slightly longer regimen with increasing doses of primaquine could allow to safely treat all patients with vivax malaria.
I am broadly interested in applied and theoretical statistics, causal inference, applied genetics and pharmacology. I am a believer in Bayes but will go with whatever works best. Most of my work has been related to falciparum and vivax malaria. I have a particular interest in G6PD deficiency: how to model haemolysis in G6PD deficient individuals and understanding the selection mechanisms that have led to high prevalences of G6PD deficiency across the malaria endemic world.
Probabilistic classification of recurrent illness in vivax
Causal pathways in severe malaria
Chu CS. et al, (2021), Antimicrobial Agents and Chemotherapy, 65
Schilling WHK. et al, (2021), Wellcome Open Research, 6, 71 - 71
Chu CS. et al, (2021)
Watson JA. et al, (2021), eLife, 10
Guerin PJ. et al, (2021)