Borimas Hanboonkunupakarn
Research Physician
Borimas' research focuses on improving the treatment of various tropical diseases with a special emphasis on malaria. She and the team at the Clinical Therapeutics Unit (CTU) have performed phase I/II clinical trials at the Bangkok Hospital for Tropical Diseases. The team demonstrated the safety, tolerability and pharmacokinetic interactions between the commonly used antimalarial combinations such as chloroquine plus primaquine and dihydroartemisinin-piperaquine plus primaquine, which supports the use of these combinations.
With the development and spread of artemisinin-resistant Plasmodium falciparum, Borimas’s specific research interests are about finding new tools to treat and control drug-resistant malaria. She and the team involved in a multi-country, open-label, randomised clinical trial (TRACII) to evaluate the efficacy, safety, and tolerability of triple artemisinin combination therapies (TACTs), which shows high treatment failure rate of dihydroartemisinin-piperaquine in Thailand, Cambodia and Vietnam. Her main current research topics are TACTs, controlled human malaria infection model, and ivermectin for malaria control.
Recent publications
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Identification of the metabolites of ivermectin in humans
Journal article
Tipthara P. et al, (2021), Pharmacology Research & Perspectives, 9
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Research ethics in context: understanding the vulnerabilities, agency and resourcefulness of research participants living along the Thai–Myanmar border
Journal article
Khirikoekkong N. et al, (2020), International Health, 12, 551 - 559
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Prevalence and clinical manifestations of dengue in older patients in Bangkok Hospital for Tropical Diseases, Thailand.
Journal article
Chhong LN. et al, (2020), Transactions of the Royal Society of Tropical Medicine and Hygiene, 114, 674 - 681
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Advances and roadblocks in the treatment of malaria.
Journal article
Hanboonkunupakarn B. and White NJ., (2020), British journal of clinical pharmacology
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Malaria cross-sectional surveys identified asymptomatic infections of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in Surat Thani, a southern province of Thailand.
Journal article
Shimizu S. et al, (2020), International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 96, 445 - 451