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© 2015 Nature America, Inc. All rights reserved. Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.

Original publication

DOI

10.1038/nmeth.3432

Type

Journal article

Journal

Nature Methods

Publication Date

30/06/2015

Volume

12

Pages

631 - 633