Plasmodium falciparum genetic crosses in a humanized mouse model
Vaughan AM., Pinapati RS., Cheeseman IH., Camargo N., Fishbaugher M., Checkley LA., Nair S., Hutyra CA., Nosten FH., Anderson TJC., Ferdig MT., Kappe SHI.
© 2015 Nature America, Inc. All rights reserved. Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.