Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases
Lindegardh N., Davies GR., Hien TT., Farrar J., Singhasivanon P., Day NPJ., White NJ.
ABSTRACT The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.