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BackgroundEstimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS.MethodsSecondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is a national, multicenter, retrospective observational study done at 22 intensive care units in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The aim was to quantify the dynamics and determine the prognostic value of surrogate markers of wasted ventilation in patients with COVID-19-related ARDS.ResultsA total of 927 consecutive patients admitted with COVID-19-related ARDS were included in this study. Estimations of wasted ventilation such as the estimated dead space fraction (by Harris-Benedict and direct method) and ventilatory ratio were significantly higher in non-survivors than survivors at baseline and during the following days of mechanical ventilation (p 2 ratio was lower in non-survivors than in survivors (p 2 ratio. After adjustment for a base risk model that included chronic comorbidities and ventilation- and oxygenation-parameters, none of the dead space estimates measured at the start of ventilation or the following days were significantly associated with 28-day mortality.ConclusionsThere is significant impairment of ventilation in the early course of COVID-19-related ARDS but quantification of this impairment does not add prognostic information when added to a baseline risk model.Trial registrationISRCTN04346342. Registered 15 April 2020. Retrospectively registered.

Original publication




Journal article


Critical care (London, England)

Publication Date





Intensive Care Unit, Hospital Universitari General de Catalunya, Grupo Quironsalud, Carrer Pedro i Pons, 1, 08195, Sant Cugat del Vallès, Barcelona, Spain.


PRoVENT-COVID Study Group, Humans, Respiratory Function Tests, Prognosis, Respiration, Artificial, Retrospective Studies, ROC Curve, Respiratory Dead Space, Respiratory Mechanics, Adult, Intensive Care Units, Female, Male, Patient Acuity, Biomarkers, Respiratory Distress Syndrome, COVID-19