Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The Bill & Melinda Gates Foundation has approved a three-year grant that will lead to an expansion of the pharmacometric research group within MORU’s Department of Clinical Pharmacology.

Joel Tarning and pharmacometric team

Head of Pharmacology Joel Tarning will be principal investigator for the grant, Model-based drug development platforms for antimalarials, which will be based at MORU in Bangkok, Thailand.

Malaria is still the most important parasitic disease of humans, killing almost 2,000 people each day, mainly young children under the age of five in tropical areas. The increasing prevalence of artemisinin-resistant falciparum malaria in Southeast Asia is now threatening our ability to control and eliminate malaria in the region and elsewhere and jeopardizing aspirations to eliminate malaria. ACT partner drug resistance is following so there is an urgent need now for novel, safe and effective antimalarial combination treatments with different mechanism of actions. However, drug development is slow and costly and in need of optimization to accelerate the delivery of novel antimalarial drugs and combinations in the market.

The overall goal of the proposed research, which will be done at MORU Pharmacology, is to develop a novel model-based platform for antimalarial drug development and optimize the use of existing antimalarial drugs. This could accelerate the development of new antimalarial drugs substantially, reduce costs and de-risk the process of bringing new antimalarial drug combinations to clinical care.

For more information, kindly contact John Bleho

Similar stories

How did people in Europe and SE Asia experience the first COVID-19 wave?

An international team, led by Phaik Yeong Cheah, conducted an anonymous online survey from May-June 2020, asking 5,058 people in Thailand, Malaysia, United Kingdom, Italy and Slovenia to share their experiences. Anne Osterrieder and colleagues report the unequal impacts of public health measures, and the prevalence of ‘fake news’.

Recruitment surges in COPCOV COVID-19 prevention study

As high COVID-19 daily cases and highly transmissible variants risk overwhelming countries’ healthcare systems, COPCOV, the world’s last-standing large prophylaxis RCT, faces tight timelines to determine whether chloroquine/ hydroxychloroquine prevents COVID-19

Simple blood tests may help improve malaria diagnosis in clinical studies

About one-third of children diagnosed with severe malaria may instead have an alternative cause of illness, but simple blood tests could help researchers distinguish between the two and speed up research on new treatments.

ASM Editor in conversation with Nick White

Malaria continues to be a major killer, particularly in sub-Saharan Africa, affecting the world’s most vulnerable populations with more than 500,000 deaths per year, most of them African children. Emergence of resistance to antimalarial drugs is major public health issue. American Society for Microbiology Editor Dr Cesar Arias discusses with Professor Sir Nick White the latest information on this rapidly evolving field.

AMR and scrub typhus among Chiangrai Unit's research priorities

Which infections are most common in the Chiangrai region? How should we treat them and how can we improve diagnostic? Which strategies are most effective in directing antibiotic treatment? Blog by Carlo Perrone, research physician based at the Chiang Rai Clinical Research Unit in Chiangrai, Thailand.

Arjen Dondorp, Peter Horby and Rose McGready elected Academy of Medical Sciences Fellows

"Although it is hard to look beyond the pandemic right now," says President of the Academy of Medical Sciences Professor Dame Anne Johnson, "I want to stress how important it is that the Academy Fellowship represents the widest diversity of biomedical and health sciences. The greatest health advances rely on the findings of many types of research, and on multidisciplinary teams and cross-sector and global collaboration."