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  • Large trials in Myanmar, Cambodia, Laos and Vietnam on the use of targeted mass drug administration (MDA) with dihydroartemisinin/piperaquine +/- low dose primaquine showed that the intervention achieved large reductions in falciparum malaria prevalence and highlighted the importance of community engagement to achieve high population coverage. Using a novel ultrasensitive qPCR detection method, the importance of asymptomatic parasite carriage for maintaining malaria transmission in the region was described.