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The results of Mehra et al in The Lancet have had a considerable impact on public health practice and research, halted trials and caused considerable concern to participants and patients enrolled in randomised controlled trials (RCTs). This has led many researchers around the world to scrutinise in detail the publication and outline their concerns in this letter to Richard Horton, editor of The Lancet.

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Professor Sir Nicholas White was a pioneering tropical medicine specialist whose work transformed malaria treatment worldwide, as written in The Times. He championed artemisinin-based combination therapies and intravenous artesunate, saving millions of lives. As head of MORU, he built influential research networks across Asia and Africa, publishing over 1,300 papers and shaping global policy. Knighted and widely honoured, he remained active in research until his death in 2026, aged 74.