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Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). Here, we suggest that in current clinical practice in the setting of ARDS HILI may actually be of less importance than other ventilator-related factors.

Original publication

DOI

10.1152/ajplung.00443.2022

Type

Journal article

Journal

American journal of physiology. Lung cellular and molecular physiology

Publication Date

07/2023

Volume

325

Pages

L9 - L16

Addresses

Department of Intensive Care, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.

Keywords

Humans, Hyperoxia, Oxygen, Respiration, Artificial, Lung Injury, Respiratory Distress Syndrome