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Convolutional neural networks (CNNs) have become the architecture of choice for visual recognition tasks. However, these models are perceived as black boxes since there is a lack of understanding of the learned behavior from the underlying task of interest. This lack of transparency is a serious drawback, particularly in applications involving medical screening and diagnosis since poorly understood model behavior could adversely impact subsequent clinical decision-making. Recently, researchers have begun working on this issue and several methods have been proposed to visualize and understand the behavior of these models. We highlight the advantages offered through visualizing and understanding the weights, saliencies, class activation maps, and region of interest localizations in customized CNNs applied to the challenge of classifying parasitized and uninfected cells to aid in malaria screening. We provide an explanation for the models' classification decisions. We characterize, evaluate, and statistically validate the performance of different customized CNNs keeping every training subject's data separate from the validation set.

Original publication

DOI

10.1117/1.jmi.5.3.034501

Type

Journal article

Journal

Journal of medical imaging (Bellingham, Wash.)

Publication Date

18/07/2018

Volume

5

Addresses

Lister Hill National Center for Biomedical Communications, National Library of Medicine, Bethesda, Maryland, United States.