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The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC(50)) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

Original publication

DOI

10.4269/ajtmh.2004.70.395

Type

Journal article

Journal

The American journal of tropical medicine and hygiene

Publication Date

04/2004

Volume

70

Pages

395 - 397

Addresses

Faculty of Tropical Medicine, and Department of Pathobiology, Mahidol University, Bangkok, Thailand.

Keywords

Erythrocytes, Animals, Humans, Plasmodium vivax, Malaria, Vivax, Antimalarials, Statistics, Nonparametric, Inhibitory Concentration 50, Drug Resistance, Thailand