Survey of Antimicrobial Resistance in Clinical Burkholderia pseudomallei Isolates over Two Decades in Northeast Thailand
Wuthiekanun V., Amornchai P., Saiprom N., Chantratita N., Chierakul W., Koh GCKW., Chaowagul W., Day NPJ., Limmathurotsakul D., Peacock SJ.
ABSTRACT A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime ( n = 8), amoxicillin-clavulanic acid ( n = 4), or both drugs ( n = 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.