Onrapak Reamtong
Head of Discovery
My research programme focuses on therapeutics and biomarker discovery for parasitic and tropical diseases through the integration of mass spectrometry-based multi-omics and translational medicine. My work aims to generate molecular-level insights that inform drug discovery, development, and treatment strategies in endemic settings.
A central aspect of my research is the application of advanced quantitative proteomics, metabolomics, and lipidomics to characterize biological pathways associated with infection, therapeutic response, and disease progression. These approaches enable the identification of molecular signatures that can serve as biomarkers and reveal critical pathways relevant to drug targeting and efficacy.
In parallel, I advance antiparasitic drug discovery and development through drug repurposing, natural compounds, and nanotechnology-based delivery systems. Multi-omics strategies are used to identify novel drug targets, elucidate mechanisms of action, and investigate the molecular basis of drug resistance. This systems-level understanding supports the identification of key pathways involved in reduced drug susceptibility and informs the rational design and optimization of therapeutic interventions.
Through interdisciplinary collaboration and integration with clinical and field research, my programme translates multi-omics discoveries into practical applications, including candidate therapeutics, biomarkers, and improved diagnostic strategies. This work contributes to advancing precision approaches for parasitic diseases and supports the development of more effective, accessible, and sustainable interventions in endemic regions.