Microbiology and non-malaria research
- Completed a clinical trial on CRP-guided treatment in febrile primary care patients. This was accompanied by 5 additional publications describing other contextual factors relating to the trial (baseline antibiotic prescription in the sites; social science investigations regarding patient and healthcare worker perspectives on CRP testing)
- In the process of rolling out a large cluster RCT of CRP testing in Vietnam
- Produced the first of its kind menu of the costs of AMR per antibiotic drug class for LMICs and high-income settings (Antimicrob Resist Infect Control. 2018;7:98. doi: 10.1186/s13756-018- 0384-3)
- Cost-effectiveness of interventions to improve hand hygiene in healthcare workers in middle income hospital settings (J Hosp Infect. 2018;100(2):165-75. doi: 10.1016/j.jhin.2018.05.007)
- Completed first longitudinal study of MDR Klebsiella pneumoniae with whole genome sequencing (Front Microbiol. 2018;9:1197. doi: 10.3389/fmicb.2018.01197)
- Proof of concept of using machine learning approach to improve antibiotic prescribing in a resource limited hospital setting (Wellcome Open Res. 2018. doi: 10.1101/367037)
- First RCT evaluation of selective decontamination strategies in high resistance ICU settings (JAMA. 2018;320(20):2087-98. doi: 10.1001/jama.2018.13765)
- Detailed analysis of transmission dynamics of MDR Enterobacteriaceae in a Cambodian NICU, combining genomic analysis and mathematical modelling, and the first study to quantify the effects of plasmid transfer on ward-level (bioRxiv. 2018; 436006. doi: https://doi. org/10.1101/436006)
- Major new collaborations established with key US and European networks working on AMR (with CDC funding)
- New grant for work on adaptive trial designs in emerging epidemics (NIHR 2018-2021)