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We are particularly interested in understanding how drug pharmacokinetics and pharmacodynamics translate into different evolutionary pressures for the emergence and spread of drug resistant parasites. We developed a within host model that captures the dynamics of parasite asexual and sexual replication cycles, thus allowing us to correlate the total infectiousness of certain parasite populations, given the administration of different drug regiments and combinations.

graphs showing sexual parasite densities and infectiousness
Dynamics of asexual parasite densities and infectiousness derived from sexual parasite densities over time.