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PLATCOV researchers find dramatic acceleration of SARS CoV2 viral clearance rates since Sept 2021
MORU Bangkok
29 May 2024
Running continuously since Sept 2021, the PLATCOV trial has randomised over 1700 patients presenting with COVID19 infections. Work by PLATCOV’s Dr Phrutsamon Wongnak published in the Lancet Infectious Diseases has shown that rates of oropharyngeal viral clearance have accelerated dramatically since the trial started: A SARS CoV2 viral clearance half-life in untreated patients of around 16 hours In Sept 2021 had reduced to around 9 hours by Oct 2023. The results highlight the importance of pharmacometric platform trials like PLATCOV, so that we are prepared for the next pandemic.
Pan made Associate Professor at Oxford
Awards & Appointments MORU Bangkok
17 May 2024
In April 2024, the Head of MAEMOD, Wirichada (Pan) Pan-ngum was awarded the title of Associate Professor at the University of Oxford in recognition of her contributions to research, teaching and administration/citizenship at Oxford and beyond. Please join us in extending your heartiest congratulations to Pan for this significant honour and recognition of academic achievement. Well done, Pan!
Experts join forces to improve screening devices to detect substandard and falsified medicines
MORU Bangkok
30 April 2024
Experts from across the globe joined forces to discuss how screening technologies can be improved so they can be more widely used to detect substandard and falsified medical products.
Significant global variation in national COVID-19 treatment guidelines
MORU Bangkok
23 April 2024
A new study, led by researchers at the Infectious Diseases Data Observatory (IDDO) and the Mahidol Oxford Tropical Medicine Research Unit (MORU) at NDM, found that a large number of national guidelines recommend at least one treatment proven not to work.
Interview with Diagnostics in Tropical and Infectious Diseases(DiTi) award recipient Dr Christopher Chew
MORU Bangkok
17 April 2024
Global Health research at the University of Oxford and its partners is broad reaching, bringing significant impact across all academic disciplines of medicine, the physical and life sciences, social sciences and humanities. The Diagnostics in Tropical and Infectious Disease (DiTi) award, run by the Translational Research Office, aims to strengthen the long-term partnership between Oxford University and Mahidol University by establishing partnerships and supporting collaborative projects to develop diagnostic devices for tropical and infectious diseases, with the goal of driving more translational research initiatives in global health. Read this interview from award winner Dr Chris Chew.
Geospatial modelling study highlights Indian regions with treatment-resistant malaria parasites
MORU Bangkok
16 April 2024
An updated systematic search and review of published information from over 4,000 malaria samples has identified areas in central, eastern and north-eastern India where treatment-resistant malaria parasites could be more prevalent.
Rapid diagnostic test offers cost-effective solutions for non-malarial febrile illness
MORU Bangkok
10 April 2024
New research by the Mahidol Oxford Tropical Medicine Research Unit, explores the potential benefits of a presumptive lateral flow rapid diagnostic test in managing acute non-malarial febrile illness (NMFI) patient care in rural areas of Southeast Asia.
New rapid test for melioidosis could diagnose patients in hours, and help save lives across Asia and the tropics
MORU Bangkok
5 April 2024
Researchers have found that a new test using a CRISPR-Cas12a system (CRISPR-BP34) diagnosed patients with melioidosis, an often-fatal tropical disease caused by the bacteria Burkholderia pseudomallei, within hours, rather than days as in current bacterial culture methods, so patients could receive the correct, life-saving antibiotics faster.
Children with acute malnutrition and malaria: the double burden that increases risk of treatment failure
LOMWRU MOCRU MORU Bangkok
13 March 2024
An analysis of over 11,000 falciparum malaria individual patient data sets has found that acutely malnourished children have a higher risk of reinfections and treatment failures, even when treated with recommended doses of artemisinin-based combination therapies, currently the best malaria treatment available. The malaria parasite clearance was also likely to be longer in these children.
New study uses isotope ratio mass spectrometry to analyse origins of falsified antimalarials
LOMWRU MORU Bangkok
20 February 2024
New work from the Medicine Quality Group at IDDO and MORU pilots the use of stable isotope mass spectrometry to estimate where falsified antimalarials and their components come from. The study, published in Scientific Reports, is a collaboration between the Medicine Quality Research Group, LOMWRU, and MORU Bangkok, working with stable isotope scientists in Utah, USA.
Repurposed tests can detect falsified vaccines, study finds
LOMWRU MORU Bangkok
16 February 2024
Researchers have found that widely available rapid diagnostic tests (RDTs), typically used for common infections, can be repurposed to detect substandard and falsified (SF) vaccines, a significant but overlooked issue in global public health. Preliminary data suggests RDTs could be utilized by international organizations and regulators to screen vaccine supply chains for falsified products. This innovative approach addresses the urgent need for affordable tools to combat the threat of SF vaccines.
GRAM study reveals rising antimicrobial resistance in enteric fever across 75 countries, affecting millions
COMRU LOMWRU MORU Bangkok
15 February 2024
Findings reveal resistance patterns for a priority pathogen--also known as typhoid fever--with high mortality and morbidity in resource-constrained settings
Book chapter highlights issues of poor-quality medical products during the global pandemic
MORU Bangkok
5 February 2024
MORU' and IDDO’s Medicine Quality Research Group (MQRG) have written a chapter in a new book which examines the global issue of substandard and falsified medical products.
Advancing lab analysis of simulated samples, crucial to developing forensic techniques, is focus of FORESFA Trentino workshop
Conferences & meetings
23 January 2024
The FORESFA project's laboratory group met for a workshop in Trentino, Italy, with participants from Oxford, Edinburgh, London, and Vienna. The workshop focused on advancing the analysis of simulated samples, which are crucial to developing forensic techniques to analyse falsified medical products. Challenges in data integration, collaboration with external experts, and a workflow for the first pilot analysis of falsified samples were discussed.
Anomaly detection improves real-time dengue surveillance in Thailand
MORU Bangkok
23 January 2024
A recent study by the Mahidol-Oxford Tropical Medicine Research Unit (MORU) at NDM outlined a highly effective method for dengue surveillance. The researchers improved risk detection in real time by combining space-time modelling and anomaly detection. This will help in making dengue prevention more effective not only in Thailand but also in other regions with similar challenges.
High dose oral favipiravir does not accelerate COVID-19 viral clearance, Oxford researchers find
MORU Bangkok
19 January 2024
Giving high oral doses of the anti-influenza drug Favipiravir to adults with early symptomatic COVID-19 treatment did not accelerate viral clearance, say researchers in a study published in BMC Infectious Diseases. In fact, there was no difference in the rate of viral clearance between patients given favipiravir and patients receiving no study drug.
Neglected disease raises new ethical questions: Nipah virus control and research
MORU Bangkok
10 January 2024
Although Nipah virus gets increasing attention in epidemic preparedness, there has been almost no bioethical work on the epidemiology, prevention, and treatment. Further work on public health ethics should address communication about the modes of transmission, surveillance, measures during epidemics, and social or religious norms, as well as potential vaccine trials and the different local contexts where trials may occur, and the use of unproven therapeutics during outbreaks. Further bioethics work may help to ensure that research and public health interventions for Nipah virus disease are ethically acceptable and more likely to be effective.
Early warning systems for malaria outbreaks in Thailand
MORU Bangkok
9 January 2024
In a recent study, NDM’s Mahidol Oxford Tropical Medicine Research Unit (MORU) researchers introduced an anomaly detection system, as an early warning mechanism for potential malaria outbreaks in countries like Thailand.
Placing community health workers in remote areas key to eliminating Falciparum malaria in Myanmar and GMS
MOCRU MORU Bangkok
22 December 2023
Medical Action Myanmar successfully eliminated falciparum malaria in Eastern Myanmar within six years, employing 172 community health workers for early diagnosis and treatment. Their approach, integrating basic health services with malaria care, led to a rapid reduction in both falciparum and vivax malaria cases. This cost-effective strategy challenges traditional, labor-intensive methods, emphasizing the importance of community health workers in achieving malaria elimination in challenging, remote areas.
New MORU-led study to test a single pill to fight drug-resistant malaria in Africa and Asia
MORU Bangkok
14 December 2023
To boost the fight against drug-resistant malaria parasites now emerging in Africa, researchers will study the safety and efficacy of a fixed-dose combination (FDC) containing three antimalarial drugs currently given to patients separately in a triple artemisinin-based combination therapy (TACT) cocktail.