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A recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
Nicholas White
COVID-19 Investigators Principal Investigators Research Scientists
FRS Nicholas White - Professor of Tropical Medicine
Andrea Soult
Andrea Soult - Research Pharmacist
Thitthiphone Olinh
Thitthiphone Olinh - Research Pharmacist
Naomi Waithira
COVID-19 Investigators Graduate Students Research Scientists
Naomi Waithira - MORU head of Data Management