Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The number of studies reporting antimicrobial resistance (AMR) data has increased in Africa, South and South East Asia according to new research in the International Journal of Infectious Diseases.

Two researchers looking at data

Authors of the paper, Antimicrobial resistance patterns in bacteria causing febrile illness in Africa, South Asia and Southeast Asia: A systematic review of published aetiological studies from 1980-2015, have recommended three measures to improve surveillance of AMR nationally and regionally. These include strengthening laboratory capacity, standardised testing and reporting of antimicrobial susceptibility testing results.

AMR is a serious threat to global public health and threatens the treatment of infections caused by bacteria, viruses, parasites and fungi. Over time, these microorganisms change and no longer respond to medicines resulting in treatment failure, a risk of disease spread, more severe illness and ultimately death.

Researchers used the IDDO non-malarial febrile illness (NMFI) map to conduct a systematic review to characterise AMR patterns for bacterial causes of febrile illness in Africa and Asia. A total of 371 unique articles over a period of 30-years included the target pathogen-drug combinations.

The main findings were:

  • An increase in the number of studies reporting antimicrobial resistance data over time and a high number of studies reporting 3rd generation cephalosporin resistance in Asia for Escherichia coli and Klebsiella pneumoniae and in Africa for K. pneumoniae. 
  • An increase in the pooled proportion of resistance to fluoroquinolones in Salmonella enterica over time in both regions. 
  • Overall, there was a general paucity of data and a lack of standardisation and data quality assurance.
  • Strengthening of laboratory capacity and standardised testing and reporting of antimicrobial susceptibility testing results is required to improve surveillance of AMR both nationally and regionally. 

The full story is available on the IDDO website

Similar stories

Pilot study detects diverse DNA in ingredients of falsified tablets

A recent multidisciplinary pilot study, originating from LOMWRU and the Medicine Quality Research Group of IDDO and MORU, investigated whether bacterial, plant, fungal and animal DNA in the ingredients and from the environment (eDNA) could be detected from falsified (aka counterfeit) tablets.

COPCOV investigators meet, and prepare to submit for publication

On 15-16 Dec, COPCOV investigators from around the world met in Bangkok to review study results and plan next steps. Led by co-PIs Prof Sir Nick White and Dr Will Schilling, and funded by the Wellcome Trust, the MORU-led COPCOV ( Chloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting) is the world’s largest multinational trial of COVID-19 prevention.

Are we getting tafenoquine dosing right?

Researchers analysing clinical trial data for the new antimalarial drug tafenoquine find that higher doses are needed to cure reliably vivax malaria infection.

Constant genetic surveillance necessary to keep multidrug-resistant malaria parasite strains in check, study finds

Continually monitoring malaria parasite populations is necessary to prevent outbreaks of previously dormant multidrug-resistant malaria strains, say University of Oxford researchers. Multidrug-resistant malaria parasite strains can rapidly grow or collapse in response to public health policy changes, say the researchers in a study published today in The Lancet.

Bacterial infections linked to one in eight global deaths, according to GRAM study

Data showing 7.7 million deaths from 33 bacterial infections can guide measures to strengthen health systems, particularly in low-income settings

Combating drug-resistant malaria

MORU research has contributed to strategies to eliminate malaria in the Greater Mekong Sub-region, helping to prevent the spread of drug-resistant malaria and improving health provision and outcomes for remote communities.