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On 4 June 2020, after a week of increasing scientific concern and scrutiny, first The Lancet, then the New England Journal of Medicine, retracted studies that were based on inaccessible data. The studies have been extremely damaging to chloroquine and hydroxychloroquine COVID-19 clinical trials around the globe. MORU researchers played a key role in bringing this scandal to light, whose consequences continue to play out.
The Clinical Trials Support Group (CTSG) supports investigators conducting research for the MORU Tropical Health Network and in collaboration with MORU sister units in Vietnam and Kenya – an international endeavour both in Thailand and across Southeast Asia and Africa
The Clinical Therapeutics Unit (CTU) conducts clinical studies on the treatment of uncomplicated malaria and analyses and models pathological responses in malaria, G6PD deficiency, vivax relapse and anti-infective drug pharmacometric and pharmacodynamics data.
MORU Epidemiology studies the factors that contribute to the risk of different diseases and how to reduce those risks. The research portfolio includes clinical studies, descriptive epidemiology, and statistical and mathematical modelling of human diseases in South and Southeast Asia and Africa with a focus on malaria, dengue, novel pathogens and environmental health.
Paying attention to the public and communities is essential to make our programmes ethical and trustworthy, to maximise their success and impact.
The Mathematical and Economic MODelling (MAEMOD) Department’s main research focus is mathematical and economic models supporting investigations into the transmission, control and elimination of tropical diseases.
Established in 2003 to meet a need for accurate, sensitive antimalarial drug measurements in the biological fluids of clinical trials patients, MORU’s Department of Clinical Pharmacology is now one of the world’s leading laboratories for antimalarial drug pharmacology.
Opened in 1986, the Microbiology Department conducts research on: melioidosis, scrub typhus and other rickettsial infections; antimicrobial resistance; leptospirosis; the epidemiology of infectious diseases; sepsis and severe sepsis; the evaluation of diagnostic tests; and the immunology and cell biology of infectious diseases.
The aim of the Malaria & Critical Illness Department at MORU is to improve health through research that addresses threats arising from malaria for billions of people who live in malaria endemic zones around the globe. Our research focuses on the diagnosis, pathophysiology, treatment including the raising issue of drug resistance, prevention and elimination of malaria