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Several projects are on-going investigating efficacy, safety, and potential drug-drug interactions of antimalarial drugs when used in novel combination treatments. Particular focus will be on triple combination therapy with or without other transmission and/or vector control agents such as primaquine and/or ivermectin. Pharmacokinetic and pharmacodynamic modelling of these combinations aims to inform treatment policy of multi-drug resistant malaria and provide treatment options in malarial elimination campaigns.