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Physiologically based pharmacokinetic (PBPK) modelling

We will initiate more projects using a PBPK methodology. These analyses will be carried out using the software SimCYP, which has been developed specifically for PBPK modelling. Initially, we will investigate the impact of pregnancy on the pharmacokinetics of piperaquine by utilizing the built-in pregnancy module in SimCYP and compare to clinical data available at the department.