Antimalarial dose optimisation
We will continue to optimise antimalarial dose regimens in young children and pregnant women. Drug exposure does not commonly scale linearly with body weight, and small children often need a higher dosage (mg/kg) compared to adults to achieve equivalent exposures. Drug exposure is often different in pregnant women compared to non-pregnant adults due to physiological alterations during pregnancy. Individual clinical trial analyses and large-scale meta-analysis on the pharmacokinetic properties of antimalarial drugs will be conducted and reported.