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We will continue to optimise antimalarial dose regimens in young children and pregnant women. Drug exposure does not commonly scale linearly with body weight, and small children often need a higher dosage (mg/kg) compared to adults to achieve equivalent exposures. Drug exposure is often different in pregnant women compared to non-pregnant adults due to physiological alterations during pregnancy. Individual clinical trial analyses and large-scale meta-analysis on the pharmacokinetic properties of antimalarial drugs will be conducted and reported.