Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

© 2018 by Taylor & Francis Group, LLC. Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α-[dibutylaminomethyl]-2,7-dichloro-9[pchlorobenzylidene]- 4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).

Original publication

DOI

10.1201/9781315152110

Type

Chapter

Book title

Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition

Publication Date

01/01/2017

Pages

2974 - 2988