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© 2018 by Taylor & Francis Group, LLC. Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α-[dibutylaminomethyl]-2,7-dichloro-9[pchlorobenzylidene]- 4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).

Original publication





Book title

Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition

Publication Date



2974 - 2988