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AbstractISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global uptake of this resource has resulted in a large, standardised collection of comprehensive clinical data from hundreds of sites across dozens of countries. Data are analysed regularly and reported publicly to inform patient care and public health response. This report is a part of a series and includes the results of data analysis on 8 April 2021.We thank all of the data contributors for their ongoing support.Report highlights includeData have been entered for 340,312 individuals from 1609 sites across 54 countries.The analysis detailed in this report only includes individuals:for whom data collection commenced on or before 1 February 2021.ANDwho have laboratory-confirmed or clinically-diagnosed SARS-COV-2 infection.For the 264,496 cases who meet eligibility criteria for this report:The median age is 61 years.The five most common symptoms at admission were shortness of breath, cough, history of fever, fatigue/malaise, and altered consciousness/confusion. Children and older adults were less likely to display typical symptoms, and around 40% of patients >80 years experienced confusion.A total of 19% of patients were admitted at some point during their illness into an intensive care unit.Antibiotic use is high (79.9% of patients received antibiotics - the choice of antibiotic and specific indication have not yet been determined.)Altered consciousness/confusion was also relatively frequent (28,190/130,157) and most common in elderly patients. Overall, elderly patients are less likely to present with URTI symptoms.To access previous versions of ISARIC COVID-19 Clinical Data Report please use the link below:https://isaric.org/research/covid-19-clinical-research-resources/evidence-reports/

Original publication

DOI

10.1101/2020.07.17.20155218

Type

Journal article

Publisher

Cold Spring Harbor Laboratory

Publication Date

25/07/2020