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The CD36 and ICAM-1 glycoproteins on vascular endothelial cells have been implicated as cytoadherence receptors for Plasmodium falciparum-infected erythrocytes (IRBC). Adhesion of IRBC from Thai patients with uncomplicated and severe falciparum malaria to purified CD36 or ICAM-1 and to C32 melanoma cells was compared. All malaria isolates bound to solid phase-adsorbed CD36 and to fluid-phase 125I-labeled CD36. IRBC adhesion to purified ICAM-1 varied widely, and no correlation with clinical severity of disease was observed. The cytoadherent phenotype of IRBC was modulated by selective panning on plates coated with purified CD36 or ICAM-1. IRBC selected by panning on CD36+, ICAM-1+ melanoma cells bound to cells that express surface CD36 but not to CD36-deficient cells, indicating that CD36 exerts a strong selective pressure on the IRBC cytoadherent phenotype. IRBC adhesion to CD36 and ICAM-1 suggests that P. falciparum parasites may use these receptors in vivo to promote parasite survival and immune evasion.

Original publication

DOI

10.1093/infdis/164.1.163

Type

Journal article

Journal

The Journal of infectious diseases

Publication Date

07/1991

Volume

164

Pages

163 - 169

Addresses

Department of Medicine, Walter Reed Army Medical Center, Washington, DC.

Keywords

Erythrocytes, Tumor Cells, Cultured, Animals, Humans, Plasmodium falciparum, Malaria, Melanoma, Cell Adhesion Molecules, Intercellular Adhesion Molecule-1, Receptors, Cell Surface, Antigens, CD, Flow Cytometry, Cell Adhesion, CD36 Antigens