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Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.

Original publication




Journal article


The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Publication Date





279 - 282


Advanced Research Unit of the University of São Paulo in Rondônia, Rondônia, Brazil.


Humans, Malaria, Falciparum, Acute Disease, Mefloquine, Antimalarials, Adolescent, Adult, Aged, Middle Aged, Child, Child, Preschool, Infant, Female, Male