The In-vitro susceptibilities of toxigenic Corynebacterium diphtheriae isolated between 1992 and 1996 in Viet nam
Parry CM., Hoa NTT., Wain J., Kneen R., Dung NM., Giao PN., Hien TT., White NJ.
The in-vitro activities of 12 antibiotics against 88 toxigenic strains of C.diphtheriae isolated from children with clinical diphtheria between 1992 and 19% were determined by agar dilution. All isolates were susceptible to penicillin, ampicillin, cefuroxime, ceftriaxone, ciprofloxacin and gentamicin. 27/88 (31%) isolates were resistant to one or more of the other antibiotics including tetracycline in 21/88 (24%), erythromycin and azithromycin in 13/88 (15%), chloramphenicol in 7/88 (8%), trimethoprim in 3/88 (3%) and rifampicin in 1/88(1%). 14/88 isolates were resistant to several antibiotics [TetREryR (7), TetRChlorR (2), TetREryR ChlorR (2) and TetRChlorRTrimRRifR (1)]. The emergence of resistance to multiple antibiotics in C.diphtheriae is of concern.