Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria
Loughland JR., Woodberry T., Boyle MJ., Tipping PE., Piera KA., Amante FH., Kenangalem E., Price RN., Engwerda CR., Anstey NM., McCarthy JS., Minigo G.
<jats:p>This study identified CD16+ DCs as the only blood DC subset distinctively activated during primary blood-stage human Plasmodium infection. As TNF/IL-10 coproducers, CD16+ DCs contribute to early inflammatory processes, yet P falciparum restimulation skewed cytokine responses further towards IL-10 production.</jats:p>