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Allelic variation in the Plasmodium falciparum circumsporozoite protein (CS) gene has been determined by sequencing the immunodominant T-cell epitopes, Th2R and Th3R, from 95 isolates from two malaria-endemic areas in the west of Thailand. Comparison with a reference sequence revealed only non-synonymous point mutations in the two epitope regions. Point mutations were found outside these epitopes in a minority of samples, and all but four were also non-synonymous. A relatively high number of variants, 11 Th2R and 9 Th3R, were detected and comprised some that had not been previously observed. However, the Th2R*05 and the Th3R*01 allelic variants predominated, as they were found in more than 70% of the 101 sequences obtained.

Type

Journal article

Journal

The Southeast Asian journal of tropical medicine and public health

Publication Date

06/2004

Volume

35

Pages

281 - 287

Addresses

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Keywords

Animals, Plasmodium falciparum, Malaria, Falciparum, Protozoan Proteins, DNA, Protozoan, Antigens, Protozoan, Epitopes, T-Lymphocyte, Base Sequence, Repetitive Sequences, Nucleic Acid, Polymorphism, Genetic, Alleles, Thailand