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Burkholderia pseudomallei causes melioidosis and is believed to be an intracellular pathogen in human and animal disease. The uptake of B. pseudomallei by mouse peritoneal macrophages and cells in tissue culture was examined by electron microscopy. In all the systems studied B. pseudomallei were phagocytosed and apparently inhibited the normal processes of intracellular killing. Destruction of the phagosome membrane occurred and the bacteria escaped into the cytoplasm.

Type

Journal article

Journal

Microbios

Publication Date

01/1998

Volume

94

Pages

35 - 45

Addresses

London School of Hygiene and Tropical Medicine, Great Britain.

Keywords

Cell Line, Hela Cells, U937 Cells, Lysosomes, Phagosomes, Macrophages, Peritoneal, Animals, Humans, Mice, Burkholderia pseudomallei, Melioidosis, Microscopy, Electron, Phagocytosis, Thailand