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Severe Plasmodium falciparum malaria kills many African children, and lack of antibody immunity predisposes to severe disease. A critical antibody target is the P. falciparum erythrocyte membrane 1 (PfEMP1) family of multidomain proteins, which are expressed on the infected erythrocyte surface and mediate parasite sequestration in deep organs.

Original publication

DOI

10.1128/iai.00435-21

Type

Journal article

Journal

Infection and Immunity

Publisher

American Society for Microbiology

Publication Date

17/02/2022

Volume

90