Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion

Imwong M., Suwannasin K., Srisutham S., Vongpromek R., Promnarate C., Saejeng A., Phyo AP., Proux S., Pongvongsa T., Chea N., Miotto O., Tripura R., Nguyen Hoang C., Dysoley L., Ho Dang Trung N., Peto TJ., Callery JJ., van der Pluijm RW., Amaratunga C., Mukaka M., von Seidlein L., Mayxay M., Thuy-Nhien NT., Newton PN., Day NPJ., Ashley EA., Nosten FH., Smithuis FM., Dhorda M., White NJ., Dondorp AM.

Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion.

DOI

10.1128/aac.01121-21

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

17/11/2021

Volume

65

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