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<i>Plasmodium malariae</i> is a neglected malaria parasite. It has wide geographic distribution and, although often associated with mild malaria, is linked to a high burden of anemia and nephrotic syndromes. Here, we report a cohort study conducted in the Kanchanaburi Province of Thailand during May 2013-June 2014 in which <i>P. malariae</i> infection was detected. Of the 812 study participants, two were found to be infected with <i>P. malariae</i>. One had an infection that led to acute malaria, but the other was positive for <i>P. malariae</i> at multiple visits during the study and apparently had chronic asymptomatic infection. Such persistent infection may explain how <i>P. malariae</i> has been able to thrive at very low prevalence and represents a challenge for malaria elimination.

Original publication

DOI

10.4269/ajtmh.18-0597

Type

Journal article

Journal

The American journal of tropical medicine and hygiene

Publication Date

05/2019

Volume

100

Pages

1164 - 1169

Addresses

Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Keywords

Humans, Plasmodium malariae, Malaria, Prevalence, Cohort Studies, Endemic Diseases, Geography, Adult, Middle Aged, Myanmar, Thailand, Female, Male, Asymptomatic Infections, Indigenous Peoples