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<jats:title>ABSTRACT</jats:title><jats:p><jats:italic>Plasmodium</jats:italic>species<jats:italic>ex vivo</jats:italic>sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC<jats:sub>50</jats:sub>) of<jats:italic>P. vivax</jats:italic>and<jats:italic>P. falciparum</jats:italic>to artesunate and chloroquine relative to results with the paired leukocyte-free treatment. Although leukocyte removal is not an essential requirement for the conduct of<jats:italic>ex vivo</jats:italic>assays, its use has important implications for the interpretation of temporal and spatial antimalarial sensitivity data.</jats:p>

Original publication

DOI

10.1128/aac.01103-10

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

03/2011

Volume

55

Pages

1300 - 1304