Sequential Open-Label Study of the Safety, Tolerability, and Pharmacokinetic Interactions between Dihydroartemisinin-Piperaquine and Mefloquine in Healthy Thai Adults

Hanboonkunupakarn B., van der Pluijm RW., Hoglund R., Pukrittayakamee S., Winterberg M., Mukaka M., Waithira N., Chotivanich K., Singhasivanon P., White NJ., Dondorp AM., Tarning J., Jittamala P.

Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and mortality, but resistance to artemisinins and their partner drugs is increasing in Southeast Asia, threatening malaria control. New antimalarial compounds will not be generally available soon.

DOI

10.1128/aac.00060-19

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

08/2019

Volume

63

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