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The prophylactic potential of moxifloxacin and gatifloxacin was assessed in comparison with doxycycline, an established therapeutic antibiotic, to limit or control infection by Brucella melitensis in an experimental mouse model, determined by reduced bacterial burden in the spleen. Although moxifloxacin was found to have a small protective effect when administered 6 h following infection, neither moxifloxacin nor gatifloxacin showed significant efficacy in vivo. In comparison, doxycycline provided significant protection when prophylaxis was started at 6 h, 7 days or 14 days following infection. Overall, these results confirm the utility of doxycycline in the prophylaxis of brucellosis and suggest that neither moxifloxacin nor gatifloxacin are likely to be valuable for post-exposure prophylaxis of Brucella infection.

Original publication

DOI

10.1016/j.ijantimicag.2009.06.018

Type

Journal article

Journal

International journal of antimicrobial agents

Publication Date

11/2009

Volume

34

Pages

471 - 473

Addresses

Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK. hsatkins@dstl.gov.uk

Keywords

Spleen, Animals, Mice, Inbred BALB C, Mice, Brucella melitensis, Brucellosis, Aza Compounds, Quinolines, Fluoroquinolones, Doxycycline, Anti-Bacterial Agents, Treatment Outcome, Antibiotic Prophylaxis, Colony Count, Microbial, Female