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The prophylactic potential of ciprofloxacin was assessed in comparison with doxycycline, an established therapeutic antibiotic, to limit or control infection by Brucella melitensis in an experimental mouse model. Ciprofloxacin treatment reduced bacterial loads in the spleens of challenged mice when administered prior to or at the same time as the bacterial challenge. In comparison, doxycycline provided much greater reductions in bacterial counts, even when treatment was initiated after infection. Doxycycline was able to protect against B. melitensis when administered for 5 days from 24 h after infection and for at least 28 days after cessation of the antibiotic. Overall, these results confirm that ciprofloxacin is less effective than doxycycline but suggest that it may have some utility in providing protection against low-level infections. Combination studies are indicated.

Original publication

DOI

10.1016/j.ijantimicag.2009.04.006

Type

Journal article

Journal

International journal of antimicrobial agents

Publication Date

11/2009

Volume

34

Pages

474 - 476

Addresses

Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK. hsatkins@dstl.gov.uk

Keywords

Spleen, Animals, Mice, Inbred BALB C, Humans, Mice, Brucella melitensis, Brucellosis, Ciprofloxacin, Doxycycline, Anti-Bacterial Agents, Treatment Outcome, Antibiotic Prophylaxis, Colony Count, Microbial, Female