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We determined complete viral genome sequences from three British healthcare workers infected with Ebola virus (EBOV) in Sierra Leone, directly from clinical samples. These sequences closely resemble those previously observed in the current Ebola virus disease outbreak in West Africa, with glycoprotein and polymerase genes showing the most sequence variation. Our data indicate that current PCR diagnostic assays remain suitable for detection of EBOV in this epidemic and provide confidence for their continued use in diagnosis.

Original publication

DOI

10.2807/1560-7917.es2015.20.20.21131

Type

Journal article

Journal

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Publication Date

21/05/2015

Volume

20

Addresses

Public Health England, Porton Down, Salisbury, United Kingdom.

Keywords

Humans, Hemorrhagic Fever, Ebola, Sequence Analysis, Disease Outbreaks, Phylogeny, Genome, Viral, Travel, Health Personnel, Sierra Leone, Ebolavirus, Epidemics