Giving paracetamol (acetaminophen) to patients ill with severe malaria made them less likely to develop potentially fatal kidney failure. Each year severe malaria causes close to half a million deaths globally. Acute kidney injury occurs in 40% of adults and at least 10% of children with severe malaria, killing an estimated 40% of these adults and 12-24% of the children. The study reported for the first time that giving regular doses of paracetamol protects the kidney in adult patients with severe falciparum malaria.
FIEBRE aims to design new evidence-based guidelines to manage fever, thereby ensuring that patients get drugs that give them the best chance of recovery, and thereby help stop the spread of antimicrobial resistance (AMR), a major global health problem.
In collaboration with Cambodian authorities, MORU are running the Village Drama Against Malaria project for the third year. The project, which runs in 10 remote villages in March 2018, aims to create awareness about malaria prevention and early treatment.
Melioidosis is a bacterial infection that quietly causes thousands of deaths each year. Meet Direk Limmathurotsakul, the doctor who made it his mission to make the world take notice.
To fight the growing global threat of antibiotic-resistant bacteria, food labels around the world should include an \u2018antibiotic footprint\u2019 section that clearly shows the type and amount of antibiotics used to produce that food, say scientists in a study led by Associate Professor Direk Limmathurotsakul.
Interested in science? Looking for a fun night out? Want to know what Pint of Science is all about? Come and join us for a one-night-only special, Casa Azul in Bangkok on the 1st February, where three world-class researchers will delve deep into the world of science.
Wellcome is announcing new collaborations with six institutions to find new ways to translate scientific discoveries into real world impact. The partnership with MORU will focus on closing the gap between research and implementing interventions, building capacity and expertise to support early translation to improve the health of people in low-income countries.
Professor Arjen Dondorp and colleagues are inching their way across the fringes of five Southeast Asian countries to test a triple combination therapy of antimalarial drugs. Results from the trial, being conducted in rural corners of Cambodia, Laos, Myanmar, Thailand and Vietnam, are due by mid-2018. This trial is also mentioned in the New York Times.
A collaboration between the University of Oxford and Thailand\u2019s Mahidol University has been shortlisted for the prestigious 2017 Newton Prize for its project aiming to understand the early stages of scrub typhus in Thailand.
Congratulations to Professor Sir Nick White, elected to the National Academy of Medicine (US). Election to the Academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.
The world\u2019s number-one treatment for malaria is on the brink of failure because of a new strain of drug-resistant parasites\u200a\u2014\u200aunless health policymakers take action. Professor Sir Nicholas White says that the mosquito-borne parasite responsible for severe malaria is now showing resistance to the prime treatment, Artemisinin Combination Therapy (ACT), across South-East Asia. If this resistance jumps to Africa, he warns, the tragedy will be on a massive scale.
A highly drug resistant malaria \"superbug\" from western Cambodia is now present in southern Vietnam, leading to alarming failure rates for dihydroartemisinin (DHA)-piperaquine \u2014 Vietnam\u2019s national first-line malaria treatment, leading malaria scientists warn.
At their Annual Meeting 13 Sept, the Trustees of the Royal Society of Tropical Medicine and Hygiene (RSTMH) awarded MORU\u2019s Dr Direk Limmathurotsakul its Emerging Leaders Award.
The University of Oxford has conferred the title of Associate Professor to Yoel Lubell, Head of Economics and Translational Research at MORU, to Olivo Miotto from the Centre for Genomics and Global Health at MORU, and to Ronald Geskus from OUCRU. Louise Thwaites, Clinical Research Fellow at OUCRU, was appointed University Research Lecturer.
The WorldWide Antimalarial Resistance Network (WWARN) has been shortlisted for a 2017 Times Higher Education (THE) Award in the \u2018International Collaboration of the Year\u2019 category.
On 30 Aug 2017, Professor Lisa White, Head of Mathematical/Economic Modelling (MAEMOD) at MORU, led an engaging interactive Bangkok Scientifique session on the uses of mathematical modelling in infectious diseases at Caf\u00e9 Tartine in Bangkok.
Changing home designs and materials to make homes cooler and harder for mosquitoes to enter could reduce malaria transmission in sub-Saharan Africa, according to a new study in The Lancet Planetary Health.
An existing malaria rapid diagnostic test (RDT) can be adapted to predict the delayed anaemia that can complicate severe malaria in patients treated with artemisinin-based antimalarial drugs
On Tues 6 June 2017, researchers vaccinated volunteers and began Mahidol University\u2019s study of the malaria vaccine RTS,S/AS01. This is the first study in Asia of the vaccine, an advanced product that has received regulatory approval in Europe.
5 June 2017, Bangkok (Thailand) \u2013 Doing a rapid test for G6PD deficiency before prescribing the antimalarial drug primaquine to P. vivax malaria patients could be a cost-effective way to improve thousands of lives, say researchers in a study published in PLOS Neglected Tropical Diseases.
Following the recognition in New Year\u2019s Honours for his services to tropical medicine and global health, on 19 May 2017 Professor Sir Nicholas White, Professor of Tropical Medicine at Oxford and Mahidol University Thailand, Fellow of St John's College, and Chairman of the Wellcome Trust's South East Asian Research Units was made a Knight Commander of the Order of St Michael and St George by the Prince of Wales. The investiture took place at Buckingham Palace, London, UK.
Thailand and SE Asia\u2019s first Pint of Science Festival kicked Pint-of-Science1 off on Mon 15 May with a look at Killer Bugs: Disease, Detection and Destruction and an enthusiastic reception from over 50 attendees that included scientists from MORU and other institutions, business people with a background in science and students.
A key focus of MORU is building scientific research capacity in Thailand and SE and South Asia. One way we do this is by hosting students in a world-class research environment. In this video, you\u2019ll hear from some of our current students about why living and studying in SE Asia and at MORU is such a great experience.
The first ever Pint of Science Festival in Thailand (and the first in South East Asia) will be held on the 15th to 17th May, 2017. Come and join us at FabCafe Bangkok to hear about exciting science, from cave paintings to leprosy, epidemics to genetics.
The Faculty of Tropical Medicine (FTM), Mahidol University, Thailand hosted a Congratulations party to honour Professor Sir Nicholas J. White, FRS, OBE on the occasion of his receiving Knight Commander of the Order of St. Michael and St. George from the United Kingdom for services to Tropical Medicine and Global Health.
A lineage of multidrug resistant P. falciparum malaria has widely spread and is now established in parts of Thailand, Laos and Cambodia, causing high treatment failure rates for the main falciparum malaria medicines, artemisinin combination therapies (ACTs)
In the largest study of its kind, a team of researchers led by MORU and WWARN in Bangkok developed a pharmacokinetic model that enabled a revised dose regimen to safely treat all malaria patients including young children with dihydroartemisinin-piperaquine (DP), a widely used antimalarial and a first-line treatment against malaria recommended by the World Health Organization (WHO).
Professor Nicholas White, OBE, Professor of Tropical Medicine at Oxford and Mahidol University, Thailand, Fellow of St John's College, and Chairman of the Wellcome Trust's South East Asian Research Units, is appointed a Knight Commander of the Order of St Michael and St George for services to tropical medicine and global health.
In a first, scientists used computer simulations to identify the vaccines most likely to be effective against respiratory syncytial virus (RSV), the most common cause of infant severe pneumonia worldwide.
This week marks the opening of a series of performances of Fishy Clouds, a MORU collaboration with innovative Bangkok-based B-floor Theatre group. Produced following a 6-month WT-funded research residency at MORU, Fishy Clouds is a 40-45 minute puppet theatre performance that focuses on antimicrobial resistance and the ethics of research with children. It is part of MORU's Public Engagement activities to make science more accessible to a wider public including children and young people.
Multidrug-resistant bacterial infections cause more than 19,000 excess deaths a year in Thailand alone, according to a study published today in eLife Sciences Publications. In a first for Thailand, the study systematically examined microbiology laboratory and hospital databases from nine public hospitals in Northeast Thailand and compared them to Thailand\u2019s national death registry to estimate that 19,122 deaths in Thailand in 2010 were excess deaths caused by multidrug-resistant bacterial infections.
We are delighted to announce that several MORU Network colleagues were honoured in the recent University of Oxford Recognition of Distinction rounds. Clockwise from top left: Joel Tarning was awarded the title of Professor of Clinical Pharmacology and Lisa White Professor of Modelling and Epidemiology. Stuart Blacksell, Susanna Dunachie, Paul Turner, Richard Maude, Frank Smithuis and Phaik Yeong Cheah were each awarded the title of Associate Professor.
Last week, the Village Drama Against Malaria initiative held its first performance in O Treng (Reed River), a remote rural Cambodian village that suffers from malaria. Over 200 people, more than half the village, attended the performance, which featured five village singers and primary school kids dressed as mosquitoes singing a song about malaria.
New and unexpected health threats have emerged in Asia that could weigh on the world's fastest growing and most dynamic region. Diseases associated with obesity and smoking are rising, and will cause tens of millions of deaths from heart and lung disease and cancer in coming decades. But alongside these lifestyle-associated conditions, the old foe of infectious disease is reemerging and threatens to cause an even greater health and economic disaster.
No one knows exactly why resistance to malaria drugs always emerges first in this remote western province of Cambodia, nestled in the Cardamom Mountains. \u201cThe reasons are as much social as biological,\u201d says malariologist Tom Peto, who is here in this dusty, unremarkable-looking town battling the latest threat to global malaria control: multiple drug\u2013resistant (MDR) malaria.
The Tracking Resistance to Artemisinin Collaboration II (TRACII) study has begun recruitment, with about 180 subjects enrolled to date in 12 sites in seven countries in Asia and Africa, researchers announced at the second TRACII investigators\u2019 meeting held 7 March in Bangkok.
Dr Joel Tarning from MORU discusses his New England Journal of Medicine editorial on treating malaria in pregnancy, outlining new evidence on the effectiveness of artemisinin-combination therapies in pregnant women with malaria.
Melioidosis, a difficult to diagnose deadly bacterial disease, is likely to be present in many more countries than previously thought, reports a paper published online today in the journal Nature Microbiology. The study predicts that melioidosis is present in 79 countries, including 34 that have never reported the disease.
The inaugural competition for this prize is a Student Poster Competition, which will be held at MORU Bangkok, between 11am-2pm on Monday 30th November 2015 in the Similan Room. Niklas was a great advocate of student activity, and supervised numerous students as part of his role as Head of Pharmacology.
![\"Health](\"https://www.tropmedres.ac/news/paracetamol-protects-kidney-in-severe-malaria-patients/responsive_image?ratio=r16x9&scale=w760\")
\n \n \n\n\n