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\n \n\n \n \n \n \n MORU Bangkok\n \n \n\n \n\n\n
\n \n\n \n6 March 2019
\n \n \n \nLorenz Von Seidlein tells SciDev.Net that mass drug administration as \u201cpresumptive treatment\u201d to clear the parasite reservoir was carried out in eight villages spread across Cambodia, Lao PDR, Myanmar and Vietnam. By the third month, the prevalence of P. falciparum had decreased by 92 % in those villages. Over the subsequent nine months, P. falciparum infections returned but stayed well below baseline levels, showing that MDA can stop transmission of falciparum malaria and reduce its prevalence in SE Asia, where resistance to artemisinin has hampered elimination efforts.
\n \n\n \n \n\n \n\n \n \n \n \n MORU Bangkok\n \n \n\n \n\n\n
\n \n\n \n26 February 2019
\n \n \n \nOn 12 Feb 2019, Professor Arjen Dondorp published a new book: Sepsis Management in Resource-limited Settings. The result of a 3-year project led by MORU and the European Society of Intensive Care Medicine (ESICM), the book was written by critical care physicians from around the globe.
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\n \n\n \n12 February 2019
\n \n \n \nOn 24-25 Jan 2019, investigators met in Bangkok to launch the Developing Triple Artemisinin-based Combination Therapies (DeTACT) Project. Led by MORU and funded by UKaid and the UK Department for International Development (DfID), DeTACT is a large, 14 site trial in 8 African and 5 Asian countries that will study the efficacy, safety and tolerability of two Triple Artemisinin Combination Therapy (TACT) combinations, using combinations of existing antimalarial drugs.
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\n \n\n \n18 January 2019
\n \n \n \nA recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
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\n \n\n \n16 January 2019
\n \n \n \nDoctors in Northern Cambodia are trialling a new drug combination therapy in a bid to stop the spread of drug resistant strains of malaria.
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\n \n\n \n18 December 2018
\n \n \n \nAn inspiring doctor and scientist of great compassion and intellect, Sir David Weatherall died 8 Dec 2018. A Nuffield Professor of Medicine, founder of the MRC Weatherall Institute of Molecular Medicine and a member of Wellcome\u2019s Board throughout the 1990s, Sir David was instrumental in the creation of MORU back in 1979.
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\n \n\n \n18 December 2018
\n \n \n \nA new Piperaquine Pharmacokinetics in Pregnancy Study Group is now open for participation at WWARN. The analysis hopes to determine the effect of pregnancy on the pharmacokinetic (PK) properties of piperaquine and contribute evidence to inform decisions on the use and optimal dosing of piperaquine in pregnant women.
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\n \n\n \n12 December 2018
\n \n \n \nThis article, written by Professor Nick Day at MORU and published in the November 2018 issue of the Oxford Alumni Newsletter, describes in a nutshell all the good work our Centre is doing to promote Global Oxford.
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\n \n\n \n20 November 2018
\n \n \n \nProgress against malaria has stalled, and the disease remains a significant threat to billions of people despite the expensive, decades-long efforts to contain it. In an encouraging development, MORU reported complete success in curing hundreds of patients in Southeast Asia with new three-drug combinations mixing fast-acting artemisinin with two longer-lasting drugs. It it hoped that triple therapy should become the standard for malaria treatment.
\n \n\n \n \n\n \n\n \n \n \n \n Conferences & meetings\n \n \n \n \n MORU Bangkok\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n16 November 2018
\n \n \n \nVisit the Radcliffe Science Library before 4th January 2019 to see a new art exhibition of 14 prints illustrating the global health impact of poor quality medicines. The proliferation of poor quality medicines is an important but neglected public health problem, threatening millions of people all over the world, both in developing and wealthy countries.
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\n \n\n \n9 November 2018
\n \n \n \nOxford University has been ranked as the world's best institution for medical and health teaching and research in the Times Higher Education World University Rankings for the eighth consecutive year. This ranking is based on criteria measuring teaching, research, industry income, international outlook and citations. It was noted that both research and clinical trials are supported by our network of international research units in Africa and Asia.
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\n \n\n \n9 November 2018
\n \n \n \nA systematic review analyses the results of 177 trials conducted between 1982 and 2016, including 18,436 patients who underwent electrocardiographic evaluation during malaria clinical trials. Nick White and colleagues found that serious cardiovascular side effects, which include sudden cardiac death, are very rare in the treatment of malaria with quinoline antimalarials. The work emphasises the importance of continued pharmacovigilance with the increasing use of quinoline antimalarials in mass treatment strategies such as intermittent preventative treatment and mass drug administration.
\n \n\n \n \n\n \n\n \n \n \n \n Awards & Appointments\n \n \n \n \n LOMWRU\n \n \n \n \n MORU Bangkok\n \n \n\n \n\n\n
\n \n\n \n27 October 2018
\n \n \n \nCTMGH have been nominated for the Market Research Society President's Medal, awarded annually to an organisation that conduct extraordinary research but who might not be recognised through the usual channels. Our Centre is noted for its ingenious use of freely available online satellite images to gath data on the use of antibiotics in unmapped and inaccessible villages in rural Thailand and Laos. Researchers use the images to identify representative clusters of potential participants.
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\n \n\n \n24 October 2018
\n \n \n \nCome and meet us at the ASTMH conference, to enjoy science over a pint and bite to eat: Outbreaks, from Ebola to Zika on Mon 29th Oct. Mosquitoes, the most dangerous animals in the world on Tue 30th. Global health terror night: bats, mites and other creepy crawlies on Wed 31st. We will be at The Vintage, 3121 Magazine St, New Orleans, 7-9pm
\n \n\n \n \n\n \n\n \n \n \n \n MORU Bangkok\n \n \n\n \n\n\n
\n \n\n \n4 October 2018
\n \n \n \nOn 4 Oct 2018, the MORU Malaria Dept, in collaboration with the Global Sepsis Alliance (GSA), hosted the inaugural meeting of a proposed Asian Sepsis Alliance in Bangkok.
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\n \n\n \n28 September 2018
\n \n \n \nIn this Science blog, field researchers, Dr Giacomo Zanello, Dr Marco Haenssgen, Ms Nutcha Charoenboon and Mr Jeffrey Lienert explain the importance of continuing to improve survey research techniques when working in rural areas of developing countries.
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\n \n\n \n12 September 2018
\n \n \n \nMORU is participating in a project to reduce antibiotic resistance on farms in Asia by educating farmers. In his first 12 years working as a vet in Bangladesh, Bikash Chandra Saha routinely prescribed antibiotics. Then he learned of the devastating impact of antimicrobial resistance on human health - and it revolutionized his treatment choices.
\n \n\n \n \n\n \n\n \n \n \n \n MORU Bangkok\n \n \n\n \n\n\n
\n \n\n \n4 September 2018
\n \n \n \nA team of researchers led by Yoel Lubell at MORU and IDDO used data from the USA and Thailand to link the consumption of antibiotics with the direct and indirect costs of treating patients for five drug-resistant bacterial infections.
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\n \n\n \n22 August 2018
\n \n \n \nThe University of Oxford's Medical Sciences Divisional Panel has conferred the title of Associate Professor on three members of our academic staff: Rogier van Doorn (OUCRU), Lorenz von Seidlein (MORU) and George Warimwe (KWTRP). This title is awarded in recognition of their distinction in their respective fields and contributions to the research and teaching, and we congratulate them on their success.
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\n \n\n \n26 July 2018
\n \n \n \nScientists are racing to stamp out the disease in Southeast Asia before unstoppable strains spread. This article features MORU, SMRU and colleagues, and explains what is happening and what we are doing to eliminate drug-resistant malaria in Southeast Asia before it spreads
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