{ "items": [ "\n\n
Headed by Greg Fegan, the CTSG team is set up in three primary functional areas: Clinical Research Operations, Data Management, headed by Naomi Waithira, and Statistics, led by Mavuto Mukaka.
\n \n\n \n \nBased in newly refurbished laboratory facilities, Clinical Pharmacology use a variety of sample preparation techniques, such as solid-phase extraction and liquid-liquid extraction, in combination with LC-MS methodology for drugs measurement in biological samples. We also provide pharmacokinetic data analysis, ranging from non-compartmental analysis to model-based population assessments.
\n \n\n \n \nLed by Prof Joel Tarning, Clinical Pharmacology conducts its own research and supports the MORU Tropical Health Network and external research groups with study design, drug measurements, pharmacometric analysis and interpretation of pharmacological results.
\n \n\n \n \nHeaded by Prof Richard Maude, the Epidemiology Department at MORU works in close collaboration with other departments and units across the MORU network, national disease control programmes and a broad range of other collaborators. In all projects, the Epidemiology Department works with policy-makers as partners to address the scientific questions most pertinent to the disease control and elimination agendas and generate evidence to inform policy decisions.
\n \n\n \n \nFollowing the large multi-centre multi-country TRAC II study on triple ACTs (TACTs) to treat multi-drug resistant falciparum malaria, DeTACT, a large project funded by DFID, will expand the evaluation of TACTs to African countries and aims to have 2 different TACTs ready for deployment by the end of the project.
\n \n\n \n \nCTU underpins many of the clinical malaria studies conducted by MORU by conducting preliminary PK or safety studies. CTU will continue to evaluate new and existing antimalarial drugs in order to improve the treatment of malaria.
\n \n\n \n \nCTU has conducted pharmacokinetic studies on antimalarial drugs, anti-influenza drugs, antitrypanosomal drugs, endectocides, and the RTS,S malaria vaccine in Thai adults as a prelude to a malaria elimination evaluation. It is currently evaluating an ascending dose regimen for primaquine in G6PD deficiency.
\n \n\n \n \nLocated in a ward of the Hospital for Tropical Diseases, part of Mahidol University\u2019s Faculty of Tropical Medicine (FTM), and overseen by Prof Sasithon Pukrittayakamee, the Clinical Therapeutics Unit is staffed by experienced doctors and nurses familiar with good clinical practice guidelines and research methodologies.
\n \n\n \n \nMAEMOD conducts various projects and is part of several networks
\n \n\n \n \nSince 2015, MAEMOD has led, supported or contributed to a number of teaching, training and capacity building initiatives, research projects, public engagement activities, and scientific publications, many of them on-going and with a significant impact on the transmission, control and elimination of tropical diseases. MAEMOD currently has 7 PhD/DPhil students and 2 DPhil candidates at the Nuffield Department of Medicine, University of Oxford. Students from the Oxford IHTM MSc course have successfully completed their placements with MAEMOD projects, many of which have culminated in their first academic papers. Since 2015, members of MAEMOD have contributed to 133 publications, 31 of them in 2019 to date.
\n \n\n \n \nMAEMOD\u2019s vision remains to provide pragmatic high technology solutions in resource poor settings. We will apply appropriate cutting-edge mathematical and economic methodologies to accelerate the delivery of the life-saving clinical research conducted at MORU to those who need it most. We plan to expand our capacity building programme abroad and in Thailand, where it has resulted in increased engagement with Thai government partners.
\n \n\n \n \nLed by Asst Prof Wirichada Pan-ngum, Acting Head, MAEMOD, the Neglected Tropical Diseases Modelling (NTDM) Group focuses on regional health problems, mostly neglected tropical diseases such as leptospirosis, melioidosis, dengue, and tuberculosis.
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