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Current data of hepatitis B virus (HBV) variants associated with treatment outcome identified by next generation sequencing (NGS) are limited. This study was aimed at determining the role of baseline sequence variations in the enhancer II (EnhII), basal core promotor (BCP) and pre-core (PC) regions of HBV genotype C in patients treated with pegylated interferon (PEG-IFN). Patients with HBeAg-positive chronic hepatitis B (CHB) treated with 48-week PEG-IFN were enrolled. Combined response (CR) at week 96 was defined by HBeAg seroconversion plus HBV DNA 

Original publication

DOI

10.1007/s11262-019-01689-5

Type

Journal article

Journal

Virus genes

Publication Date

10/2019

Volume

55

Pages

610 - 618

Addresses

Faculty of Medicine, Center of Excellence in Hepatitis and Liver Cancer, Chulalongkorn University, Bangkok, Thailand.

Keywords

Humans, Hepatitis B virus, Hepatitis B, Chronic, Interferons, Hepatitis B Core Antigens, Hepatitis B e Antigens, Antiviral Agents, Treatment Outcome, Prevalence, Genotype, Mutation, Adolescent, Adult, Middle Aged, Female, Male, Promoter Regions, Genetic, Genetic Variation, Young Adult, High-Throughput Nucleotide Sequencing