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Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.

Original publication

DOI

10.1016/j.pt.2021.10.005

Type

Journal article

Journal

Trends in Parasitology

Publication Date

01/01/2021