Antimalarial drug interaction studies
An ongoing series of studies is assessing the pharmacokinetics and safety of triple artemisinin combinations (TACTs). The most important finding to date – which allowed the multinational clinical trials to proceed – was to show that mefloquine did not potentiate the effects of piperaquine on ventricular repolarisation. An assessment of the interaction between artemether-lumefantrine and amodiaquine is in progress.