Links

Ministry of Health, Govt. of Lao PDR (http://www.moh.gov.la/index_en.html)

Francophone Institute of Tropical Medicine (http://www.ifmt.auf.org)

Internal medicine and Paediatric Residency training programme
(http://www.healthfrontiers.org/Projects/Laos/laos.htm)

WHO-Vientiane (http://www.who.int/countries/lao/en/)


Publications

We publish a newsletter “The Mahosot Microbiology Review” in English and Lao, describing the results of the hospital-based work, which is distributed throughout Laos to try and disseminate the new information quickly and efficiently.

The Mahosot Microbiology Review – English language version.

MMR 1, MMR 2, MMR 3, MMR 4, MMR 5, MMR 6

The Mahosot Microbiology Review - Lao language version

MMR 4, MMR 5, MMR 6

List of publications

1. Phetsouvanh R, Phongmany S, Newton PN, Mayxay M, Ramsay A, Wuthiekanun V, and White NJ. (2001) Melioidosis and Pandora's box in Lao PDR. Clinical Infectious Diseases 32, 653 – 654.

2. Newton PN, Proux S, Green M, Smithuis F, Rozendaal J, Prakongpan S, Chotivanich K, Mayxay M, Looareesuwan S, Farrar J, Nosten F, and White NJ (2001) Fake artesunate in southeast Asia. Lancet 357, 1948-1950.

3. Soukaloun D, Kounnavong S, Pengdy B, Boupha B, Durondej S, Ollness K, Newton PN, and White NJ (2003) Dietary and socioeconomic factors associated with infantile beriberi in breastfed Lao infants. Ann Trop Paediatrics 23, 181-6

4. Newton PN, Dondorp A, Green M, Mayxay M, White NJ (2003) Counterfeit artesunate antimalarials in SE Asia. Lancet 362, 169.

5. Mayxay M, Phetsouvanh R, Phompida S, Newton PN, Khanthavong M, Vannachone B, Brockman A, White NJ (2003) A randomized comparison of oral chloroquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Lao PDR (Laos). Transactions of the Royal Society of Tropical Medicine & Hygiene 97, 343-4.

6. Mayxay M, Newton PN, Khanthavong M, Pongvongsa T, Phetsouvanh R, Phompida S, Brockman A, White NJ (2003) Chloroquine versus sulphadoxine-pyrimethamine treatment of falciparum malaria in Savannakhet province, Lao PDR; an assessment of national antimalarial drug recommendations. Clinical Infectious Diseases 37, 1021-8.

7. Mayxay M, Newton PN, Yeung S, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ (2003) An assessment of the use of malaria rapid tests by village health volunteers in rural Laos. Trop Med Int Health 9, 325-9.

8. Nair S, Williams JT, Brockman A, Paiphun L, Mayxay M, Newton PN, Guthmann JP, Smithuis FM, Hien TT, White NJ, Nosten F, Anderson TJ (2003) A selective sweep driven by pyrimethamine treatment in southeast Asian malaria parasites. Mol Biol Evol. 20, 1526-36.

9. Mayxay M, Pukrittayakamee S, Newton PN, White NJ (2004) Mixed species malaria infections in humans. Trends in Parasitology 20, 233- 240.

10. Mayxay M, Khanthavong M, Lindegårdh N, Keola S, Barends M, Pongvongsa T, Yapom R, Annerberg A, Phompida S, Phetsouvanh R, White NJ, Newton PN (2004) Randomized comparison of chloroquine plus sulphadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao PDR (Laos). Clinical Infectious Diseases 39, 1139-47.

11. Newton PN (2004) The hazards of counterfeit antimalarials in Asia. BirdingAsia - Bull Oriental Bird Club 1, 72-74.

12. Alter K, Fernandez F, Green M, Newton PN (2004) Analysis of counterfeit antimalarial drugs. Eur Pharm Rev 3, 1- 5.

13. Dondorp AM, P N Newton, M Mayxay, W Van Damme, F M Smithuis, S Yeung, A Petit, A J Lynam, A Johnson, T T Hien, R McGready, J J Farrar, S Looareesuwan, N P J Day, M D Green, N J White (2004) Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials. Trop Med Int Hlth 9, 1241-1246.

14. Newton PN, Chung WH, Phetsouvanh R, White NJ (2005) Sporotrichosis in a rice miller from the Plain of Jars, Lao PDR. Emerging Infectious Diseases 11, 1496-7.

15. Cockburn R, Newton PN, Agyarko EK, Akunyili D, White NJ (2005) The global threat of counterfeit drugs: why industry and governments must communicate the dangers. PLoS Medicine 2, e100.

16. Nash D, Nair S, Mayxay M, Newton PN, Guthmann J-P, Nosten F, Anderson TJC (2005) Selection strength and hitchhiking around two antimalarial resistance genes. Proc Roy Soc Ser B. 272, 1153-1161.

17. Phongmany, S., Phetsouvanh, R., Sisouphone, S., Darasavath, C., Vongphachane, P., Rattanavong, O., Mayxay, M., Ramsay, A.C., Blacksell, S., Thammavong, C., Syhavong, B., White, N.J., Newton, P.N. (2005) A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. Transactions of the Royal Society of Tropical Medicine & Hygiene 99, 451-458.

18. Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaserm V , Rasachack B, Phiasakha K, Soukkhaserm S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN (2006) Rickettsial infections and fever, Vientiane, Laos. Emerging Infectious Diseases 12, 256-262.

19. Mayxay M, Thongpraseuth V, Khanthavong M, Lindgårdh N, Barends M, Keola S, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ, Newton PN (2006) An open, randomized comparison of artesunate plus mefloquine versus dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in the Lao People’s Democratic Republic (Laos). Trop Med Int Health 11, 1157-1185.

20. Newton PN, McGready R, Fernandez F, Green MD, Sunjio M, Bruneton C, Phanouvong S, Millet P, Whitty CJ, Talisuna AO, Proux S, Christophel EM, Malenga G, Singhasivanon P, Bojang K; Kaur H, Palmer K, Day NPJ, Greenwood BM, Nosten F, White NJ (2006) Manslaughter by fake artesunate in Asia –will Africa be next ? PLoS Medicine 3, e197.

21. Newton PN, Green MD, Fernández FM, Day NJP, White NJ (2006) Counterfeit anti-infective medicines. Lancet Infectious Diseases 6, 602-613.

22. Fernández FM, Cody RB, Green MD, Hampton CY, McGready R, Sengaloundeth S, White NJ, Newton PN (2006) Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct-analysis-in-real-time Coupled to Time-of-flight MassSpectrometry. ChemMedChem 1, 702-705.

23. Blacksell SD, Bell D, Kelley J, Mammen MP, Wutheikanun V, Sungkakum A, Peacock SJ, Newton PN, Day NPJ (2006) The comparative accuracy of eight commercial immunochromatographic assays for the diagnosis of acute dengue virus infection. Clinical Infectious Disease 42, 1127-1134.

24. Blacksell SD, Doust JA, Newton PN, Peacock SJ, Day NP, Dondorp AM (2006) A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. Trans R Soc Trop Med Hyg 100, 775-784.

25. Blacksell SD, Khounsy S, Phetsouvanh R, Newton PN (2006) A simple and inexpensive container for the transport of biological specimens in limited resource situations. Trans R Soc Trop Med Hyg 100, 184-6.

26. Blacksell SB, Smythe L, Phetsouvanh R, Dohnt M, Hartskeerl R, Symonds M, Slack A, Vongsouvath M, Davong V, Lattana O, Phongmany S, Keoluangkot V, White NJ, Day NPJ, Newton PN (2006) Limited diagnostic capacity of two commercial assays for the detection of Leptospira IgM antibodies in Laos. Clinical and Vaccine Immunology 13, 1166-1169.

27. Hall KA, Newton PN, Green MD, De Veij M, Vandenaabele P, Pizzanelli D, Mayfong M, Dondorp A, Fernández F (2006) Characterization of counterfeit artesunate antimalarial tablets from Southeast Asia. American Journal of Tropical Medicine & Hygiene 75, 804-811.

28. Phetsouvanh R, Phongmany S, Soukaloun D , Rasachak B, Soukhaseum V, Soukhaseum S, Frichithavong K, Khounolatha S, Pengdee B, Phiasakha K, Chu V, Luansay K, Rattanavong S, Sisouk K, Keolouangkot V, Mayxay M, Ramsay A, Blacksell SD, Campbell J, Martinez-Aussel B, Heuanvongsy MM, Bounxouai B, Thammavong C, Syhavong B, Strobel M, Peacock SJ, White NJ, Newton PN (2006) Causes Of Community-Acquired Bacteremia And Patterns Of Antimicrobial Resistance In Vientiane, Laos. American Journal of Tropical Medicine & Hygiene 75, 978-985.

29. Sayasone S, Odermatt P, Vongphrachanh P, Keoluangkot V, Dupouy-Camet J, Newton PN, Strobel M (2006) A trichinellosis outbreak in Borikhamxay Province, Lao PDR. Transactions of the Royal Society of Tropical Medicine & Hygiene 100, 1126-1129

30. de Viej M, Vandenabeele P , Hall KA, Fernandez FM, Green MD, Nicholas J White, Dondorp A, Newton PN, Moens L (2007) Fast detection and identification of counterfeit antimalarial tablets by Raman spectroscopy. J Raman Spectroscopy 38, 181-187.

31. Mayxay M, Berends M; Brockman A, Jaidee A, Nair S, Sudimack D, Pongvongsa T, Phompida S, Phetsouvanh R, Anderson TJC, White NJ, Newton PN (2007) In Vitro Antimalarial Drug Susceptibility And Pfcrt Mutation Amongst Fresh Plasmodium falciparum Isolates From The Lao P.D.R (Laos). Am J Trop Med Hyg. 76, 245-250.

32. Ricci C, Nyadong L, Fernandez FM, Newton PN, Kazarian S (2007) Combined Fourier Transform Infrared Imaging and Desorption Electrospray Ionization Linear Ion Trap Mass Spectrometry for the Analysis of Counterfeit Antimalarial Tablets. Analytical and Bioanalytical Chemistry 387, 551-9.

33. Mayxay M, Taylor AM, Khanthavong M, Keola S, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ, Newton PN (2007) Thiamin deficiency and uncomplicated falciparum malaria in Laos. Trop Med Int Health 12, 1-7.

34. Mayxay M, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ, Newton PN (2007) Diagnosis and management of malaria by rural community health providers in the Lao People’s Democratic Republic (Laos). Trop Med Int Health 12, 540-46.

35. Newton PN, Fernández FM, Green MD (2007) Counterfeit and substandard antimalarial drugs. In: Travelers’ Malaria, 2nd ed (Ed., Patricia Schlagenhauf). BC Decker Inc. Hamilton, Canada, pp. 331-342.

36. Blacksell SB, Myint KSA, Khounsy S, Phruaravanh M, Mammen MP, Day NPJ, Newton PN (2007) Prevalence of Hepatitis E virus antibodies in pigs: Implications for human infections in village-based subsistence pig farming in the Lao PDR. Trans R Soc Trop Med Hyg 101, 305-7.

37. Green MD, Nettey H, Villalva Rojas O, Pamanivong C, Khounsaknalath L, Ortiz MG, Newton PN, Fernandez FM, Vongsack L, Manolin O (2007) Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality. Journal of Pharmaceutical and Biomedical Analysis 43, 105-110.

38. Mayxay M, Nair S, Sudimack D, Imwong M, Tanomsing N, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ, Anderson TJC, Newton PN (2007) Combined Molecular And Clinical Assessment Of Plasmodium falciparum Antimalarial Drug Resistance In The Lao P.D.R (Laos). Am J Trop Med Hyg 77, 36-43.

39. Slesak G, Phanthavong P, Rasphone O, Luangxay K, Anoulakkham P, Pahatsalang V, Soumphonphakdy B, White JA, Newton PN (2007) Obstructive Biliary Ascariasis With Cholangitis And Hepatic Abscesses In Laos – A Case Report With Gall Bladder Ultrasound Video. Journal of Infection 54, e233-5.

40. Nyadong L, Green MD, De Jesus VR, Newton PN, Fernandez FM (2007) Reactive Desorption Electrospray Ionization Linear Ion Trap Mass Spectrometry of Latest-Generation Counterfeit Antimalarials via Noncovalent Complex Formation. Anal. Chem 79, 2150-2157.

41. Peacock SJ, Newton PN. (2007) Public health impact of establishing the cause of bacterial infections in rural Asia. Trans R Soc Trop Med Hyg 102, 5-6.

42. Mayxay M, Khomthilat T, Souvannasing P, Phounesavath K, Vorasane B, Keomany S, Douangdala P, Philavong K, Srour L, Newton PN (2007) Factors associated with a measles outbreak in children admitted at Mahosot Hospital, Vientiane, Laos. BMC Public Health 7, 193.

43. Keomany S, Mayxay M, Souvannasing P, Vilayhong C, Stuart BL, Srour L, Newton PN (2007) Toad poisoning In Laos. American Journal of Tropical Medicine & Hygiene 77, 850-853.

44. Imwong M, Nair S, Pukrittayakamee S, Sudimack D, Williams JT, Mayxay M, Newton PN, Kim JR, Nandy A, Osorio L, Carlton JM, White NJ, Day NP, Anderson TJ. (2007) Contrasting genetic structure in Plasmodium vivax populations from Asia and South America. Int J Parasitol 37, 1013-22.

45. Chau TT, Campbell JI, Galindo CM, Van Minh Hoang N, Diep TS, Nga TT, Van Vinh Chau N, Tuan PQ, Page AL, Ochiai RL, Schultsz C, Wain J, Bhutta ZA, Parry CM, Bhattacharya SK, Dutta S, Agtini M, Dong B, Honghui Y, Anh DD, Canh DG, Naheed A, Albert MJ, Phetsouvanh R, Newton PN, Basnyat B, Arjyal A, La TT, Rang NN, Phuong LT, Van Be Bay P, von Seidlein L, Dougan G, Clemens JD, Vinh H, Hien TT, Chinh NT, Acosta CJ, Farrar J, Dolecek C. (2007) Salmonella enterica Serovar Typhi: Antimicrobial drug resistance in Asia and the molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother 51, 4315-23.

46. Blacksell SD, Mammen MP, Thongpaseuth S, Gibbons RV, Jarman RG, Jenjaroien K, Nisalak A, Phetsouvanh R, Newton PN, Day NPJ (2007) Evaluation of the Panbio dengue virus NS1 antigen detection and IgM antibody ELISAs for the diagnosis of acute dengue infections in Laos. Diagnostic Microbiology and Infectious Disease 60, 43-49.

47. Newton PN, Green MD, Fernandez F (2007) Counterfeit Artemisinin Derivatives and Africa: Update from Authors PLoS Medicine 4, e139.

48. Barennes H, Simmala C, Odermatt P, Thaybouavone T, Vallee J, Martinez-Aussel B, Newton PN, Strobel M (2007) Postpartum traditions and nutrition practices among urban Lao women and their infants in Vientiane, Lao PDR. Eur J Clin Nutr Epub.

49. Cockburn R, Newton PN, Agyarko EK, Akunyili D, White NJ (2007) Correction: The Global Threat of Counterfeit Drugs: Why Industry and Governments Must Communicate the Dangers. PLoS Medicine 4, e289.

50. Blacksell SD, Bell D, Kelley J, Mammen MP Jr, Gibbons RV, Jarman RG, Vaughn DW, Jenjaroen K, Nisalak A, Thongpaseuth S, Vongsouvath M, Davong V, Phouminh P, Phetsouvanh R, Day NP, Newton PN. (2007) Prospective study to determine accuracy of rapid serological assays for diagnosis of acute dengue virus infection in Laos. Clin Vaccine Immunol. 14, 1458-64.

51. Amornchai P, Chierakul W, Wuthiekanun V, Mahakhunkijcharoen Y, Phetsouvanh R, Currie BJ, Newton PN, Vinh Chau N, Wongratanacheewin S, Day NP, Peacock SJ. (2007) Accuracy of Burkholderia pseudomallei identification using the API 20NE system and a latex agglutination test. J Clin Microbiol 45, 3774-6.

52. Fernandez FM, Green MD, Newton PN (2008) Prevalence and Detection of Counterfeit Pharmaceuticals: A Mini Review. Ind. Eng. Chem. Res. 47,585-590

53. Keoluangkhot, V, Green M Nyadong L, Fernandez F, Mayxay M, Newton PN (2008) Impaired Clinical Response In A Patient With Uncomplicated Falciparum Malaria Who Received Poor Quality And Underdosed Intramuscular Artemether. American Journal of Tropical Medicine & Hygiene 78, 552-555.

54. Paris DH, Blacksell SD, Stenos J, Graves SR, Unsworth NB, Phetsouvanh R, Newton PN, Day NP. (2008) Real-time multiplex PCR assay for detection and differentiation of rickettsiae and orientiae. Trans R Soc Trop Med Hyg 102, 186-193

55. Rosenberg M, Phetsouvanh R, Newton PN (in press) Meliodiosis. IN: Color Atlas of Pediatric Infectious Diseases.

56. Newton PN, Fernández FM, Plançon A, Mildenhall DC, Green MD, Ziyong L, Christophel EM, Phanouvong S, Howells S, McIntosh E, Laurin P, Blum N, Hampton CY, Faure K, Nyadong L, Soong SWR, Santoso B, Zhiguang W, Newton J, Palmer K (2008) A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia. PLoS Medicine 5, e32

57. Srour L, Watt B, Phengdy B, Khansoulivong K, Harris J, Bennett C, Strobel M, Dupuis C, Newton PN (2008) Noma in Laos: a stigma of severe poverty in rural Asia. American Journal of Tropical Medicine & Hygiene 78, 539-542.

58. Barennes H, Sayasone S, Odermatt P, De Bruyne A, Hongsakhone S, Newton PN, Vongphrachanh P, Martinez-Aussel B, Strobel M, and Dupouy-Camet J (2008) A major trichinellosis outbreak suggesting a high endemicity of Trichinella infection in northern Laos. Am J Trop Med Hyg 78, 40-4

59. Phetsouvanh R, Nakatsu M, Arakawa E, Davong V, Vongsouvath M, Lattana O, Moore CE, Nakamura S, Newton PN (2008) Fatal bacteremia due to immotile Vibrio cholerae serotype O21 in Vientiane, Laos, a case report. Annals of Clinical Microbiology and Antimicrobials 7, 10.

60. Ricci C, Nyadong L, Yang F, Fernandez FM, Brown CD, Newton PN, Kazarian SG. (2008) Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry. Anal Chim Acta 623:178-86.

61. Paris DH, Blacksell SD, Newton PN, Day NP. (2008) Simple, rapid and sensitive detection of Orientia tsutsugamushi by loop-isothermal DNA amplification. Trans R Soc Trop Med Hyg 102, 1239-46

62. Paris DH, Jenjaroen K, Blacksell SD, Phetsouvanh R, Wuthiekanun V, Newton PN, Day NP, Turner GD. (2008) Differential patterns of endothelial and leucocyte activation in 'typhus-like' illnesses in Laos and Thailand. Clin Exp Immunol 153, 63-7.


63. Lee SJ, Stepniewska K, Anstey N, Ashley E, Barnes K, Binh TQ, D'Alessandro U, Day NP, de Vries PJ, Dorsey G, Guthmann JP, Mayxay M, Newton P, Nosten F, Olliaro P, Osario L, Pinoges L, Price R, Rowland M, Smithuis F, Taylor R, White NJ. (2008) The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. Malar J 7, 149

64. Dowell FE, Maghirang EB, Fernandez FM, Newton PN, Green MD (2008) Detecting Counterfeit Antimalarial Tablets by Near-Infrared Spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 48, 1011-4.

65. Newton PN, Fernández FM, Green MD, Primo-Carpenter J, White NJ (in press) Counterfeit And Substandard Anti-Infectives In Developing Countries. In: Antimicrobial Resistance in Developing Countries. Ed A Sosa. Springer.

66. Parola P, Blacksell SD, Phetsouvanh R, Phongmany S, Rolain J-M, Day NPJ, Newton PN, Raoult D (2008) Genotyping of Orientia tsutsugamushi from Humans with Scrub Typhus, Laos. Emerg Inf Dis DOI: 10.3201/eid1409.071259.

67. Newton PN, Hampton C, Alter-Hall K, Teerwarakulpana T, Prakongpan S, Ruangveerayuth R, White NJ, Day NPJ, Tudino M, Mancuso N, Fernández F (2008) Characterisation Of Yaa Chud Medicine On The Thai-Burma Border: Selecting For Drug Resistant Malaria And Threatening Public Health. Am J Trop Med Hyg Am J Trop Med Hyg 79, 662-9.

68. Nair S, Miller B, Barends M, Jaidee A, Patel J, Mayxay M, Newton PN, Nosten F, Ferdig MT, Anderson TJ. (2008) Adaptive copy number evolution in malaria parasites. PLoS Genet 4, e1000243.

69. Pybus OG, Barnes E, Taggart R, Lemey P, Markov P, Rasachak B, Syhavong B, Phetsouvanah R, Sheridan I, Humphreys IS, Lu L, Newton PN, Klenerman (2008) The Genetic History Of The Hepatitis C Virus In East Asia. Journal Virology 83, 1071-1082.

70. Phetsouvanh R, Blacksell SD, Jenjaroen K, Day NPJ, Newton PN (in press) Comparison of immunofluorescence assays, for the diagnosis of scrub typhus and murine typhus, using venous blood and finger prick filter paper blood spots. American Journal of Tropical Medicine & Hygiene

71. Newton PN, Lee SJ, Goodman C, Fernández FM, Yeung S, Phanouvong S, Kaur H, Amin AA, Whitty CJM, Kokwaro GO, Lindegårdh N, Lukulay P, White LJ, Day NPJ, Green MD, White NJ (in press) A discussion of guidelines for field surveys of the quality of medicines. PLoS Medicine

72. Angelakis E, Khamphoukeo K, Grice D, Newton PN, Roux V, Aplin K, Raoult D & Rolain JM (in press) Molecular detection of Bartonella species in rodents from the Lao PDR. Clinical Microbiology and Infection