Reducing neonatal deaths in a Refugee Camp

The United Nation's IRIN news agency has just published the following news story about SMRU's special care baby unit (SCBU) in Mae La Refugee camp.  Funding from the European Union's "Aid to Uprooted People in Thailand" grant programme supports the running costs of this SCBU and is enabling SMRU to establish similar units for the uprooted population elsewhere.


THAILAND: Neonatal care for refugees by refugees

MAE SOT, 15 September 2011 (IRIN) - Just as staff at the maternity clinic in the Mae La refugee camp began learning about special care for newborns, a baby was born six weeks premature, weighing 1.3kg. 


The medics and nurses - all ethnic Karen refugees from Myanmar - were anxious about treating the tiny boy. Resigned to his fate, the family decided to take him home for his last hours or days. The staff agreed. 


Then Claudia Turner, a British research paediatrician working in the camp, convinced them to let the clinic staff help the baby live. After a month-and-a-half in the special care baby unit (SCBU), he went home, healthy. 


"The staff suddenly realized they could do it. It boosted confidence. That feels like a pivotal moment for us here," Turner said in the office at the cluster of bamboo and thatch huts housing the Shoklo Malaria Research Unit (SMRU) maternity clinic. "Babies do die, but not all babies have to die, and we do our best." 


Turner has been training Karen refugee medics and nurses in neonatal care since 2007, when she set up the clinic's SCBU in Mae La, the largest camp, housing 45,000 of the estimated 145,000 refugees living in nine camps along the Thai-Burmese border. 

"Forty percent of neonatal deaths happen within the first 24 hours after delivery," said Hervé Isambert, senior regional health coordinator with the UN Refugee Agency (UNHCR) in Bangkok. "This can be prevented by providing appropriate care within the first hours of life." 


The care can be as simple as cleaning the baby, providing skin to skin contact to prevent hypothermia and encouraging the mother to breastfeed within the first hour if possible, he said. 


A newborn baby in SMRU's Special Care baby Unit

 

While UNHCR does not provide healthcare in the camps, NGOs working in maternal care mostly refer severe neonatal cases to nearby hospitals, but the SMRU unit in Mae La is staffed with 10 medics and 15 nurses trained to deal with difficult cases. 

Neonatal deaths - within the first 28 days of life - have been halved in two years in Mae La. According to data, this is a model camp in terms of maternal health.

"Before that, there was no specific care or training for staff to look after very small babies," Turner said, noting that to reduce infant mortality, a key focus must be on newborns. 


"These are quite complicated cases. They [the medics] are operating on a level equivalent to doctor in the UK. It amazes me what they do," Turner said. "They're running it... they do all the work."

Of the 10 million children who die each year globally, four million succumb in the first 28 days mostly to prematurity, infections and birth complication-related asphyxia. The first week is the hardest: three million die in those first seven days. 

SMRU handles about 1,500 births each year. The neonatal unit cared for 279 babies in 2010. 

In 2007-2008, the early years of SCBU, the neonatal mortality rate was 26 per 1,000 live births, according to SMRU statistics. By 2009-2010, that figure had dropped to 12 per 1,000 live births. 


According to the UN Children's Fund, neonatal mortality nationwide in Myanmar in 2009 was 33 deaths per 1,000; in Thailand, it was eight per 1,000.  


Caring for newborns in western countries is expensive - costing upwards of US$1,000 a day, and for premature babies in a refugee camp many believed it would be too difficult and too expensive. But a month of SMRU care totals about $165. Other NGOs afford local hospital bills through health programming grants and negotiating costs. 


"People don't believe it is possible - that's what I hope to disprove. I've disproved it here, but I haven't proved that it can be used in any setting," Turner said. "Even without spending all that money, you can make an impact." 


Waves of ethnic Karen refugees and labour migrants have poured into Thailand since the 1980s. Many came to escape fighting between the Burmese government and ethnic minority groups, while others are in Thailand because of greater economic opportunities.

 

 

Tropical Diseases Modelling Network

Tropical Diseases Modelling Network (TDModNet) is a new network for mathematical modellers and their collaborators based in the tropics and working on tropical infectious diseases. There are members with a range of research experience (from graduate student to professor) and expertise (mathematicians, biologists, epidemiologists, malariologists, policy makers, geneticists, bioinformaticists, clinicians). The aim is to provide a forum to build mathematical modelling capacity in the developing world in a self-sufficient way by exploiting the pre-existing structure of the network members.

The network will achieve this by:

  • providing a forum for sharing ideas and discussing modelling research with other modellers
  • supporting informal skills transfer
  • providing formal training activities
  • developing internal quality control systems for network research output
  • nurturing new collaborations
  • providing modelling support for public health policymaking
  • raising the collective profile of the members

TDModNet had its first meeting during the Oxford Tropical Network (OTN) meeting (supported by the Wellcome Trust) in Vientiane in February 2011. TDModNet currently has a growing membership all based in the Tropics (roughly 50 members).

website: www.tdmod.net

Pathology and Pathophysiology

Pathology: Dr Gareth Turner ( This e-mail address is being protected from spambots. You need JavaScript enabled to view it. )

 

Our group provides pathology input to a number of collaborations at MORU and more widely within the Oxford Tropical Network, including projects in malaria, rickettsial disease, pneumonia, placental malaria and dengue.

 

Malaria Pathology and Pathophysiology

Working in the Department of Tropical Pathology, Mahidol University (http://www.tm.mahidol.ac.th/eng/tmpt/tmpt_index.htm), with our colleagues Prof Emsri Pongponrat, Dr Urai Chaisri and Dr Panote Prapansilp, we use pathology techniques to research the pathophysiology of malaria, including histopathology, immunohistochemistry and electron microscopy. To complement these approaches we are working with Dr Kesinee Chovitanich at MORU to develop in vitro endothelial cell models of brain and lung endothelial lines. In collaboration with the Wellcome Trust Centre for Human Genetics, Oxford, we are developing translational molecular pathology approaches to investigate the pathogenesis of cerebral malaria and other severe forms of malarial disease including lung injury and acute renal failure.

Sequestration in the Lung Sequestration in the Brain

 

The MEMA Autopsy Study (Moçambique Estúdio Malária Autópsia) in Beira

With funding from the Thrasher Foundation, USA (http://www.thrasherresearch.org/) we are conductiong an autopsy based study of the Pathology of Fatal P.falciparum malaria with our collaborator in Hospital Central de Beira, Mozambique, Dr Josefo Ferro and the MORU malaria group including Prof Arjen Dondrop and Dr Ilse Hendriksen. Tissues from these patients are being used to study the pathological features of fatal malaria in this population, and for a project studying molecular pathological investigation of gene expression in the brain and kidney in malaria.

 

Blood brain barrier in cerebral malaria

 

Placental Malaria

In collaboration with Prof Francois Nosten, Dr Rose McGready and Dr Marcus Rijken at the Shoklo Malaria Research Unit (http://www.shoklo-unit.com/About/Intro.htm) and Dr Atis Muhlenbachs (SBRI and University of Washington, Seattle) we are examining the pathology of placental malaria in P.falciparum and P.vivax infection.

 

 

Scrub TyphusOrientia tsutusgamushi in human skin biopsy eschar

We are conducting studies of the immunonopathogenesis of Orientia tsutsugamushi in scrub typhus, cloning and characterising the p56 type specific antigen to examine its role in eliciting humoral and cell mediated immune responses, in collaboration with the Oxford Protein Production Facility (http://www.oppf.ox.ac.uk/OPPF/). In collaboration with AFRIMS, Dr Allen Richards (Navy Medical Research Centre, Silver Spring, USA)and Dr Daniel Paris, we are investigating the immunopathogenesis of Scrub Typhus (Postdoctoral researcher Dr Piyanate)

 

 

 

Pneumonia – the PERCH Post mortem Lung Needle Biopsy Study

The PERCH study (Pneumonia Etiology Research for Child Health) is a multi-centre case control study of the etiology of childhood pneumonia, funded by the Gates Foundation and coordinated through Johns Hopkins Bloomberg School of Public Health (http://www.jhsph.edu/ivac/AboutPERCH.html), directed by Prof Orin Levine. Working with multiple collaborators in Africa, Bangladesh and Thailand (at the CDC/MOPH Emerging Infectious Diseases Programme) we are coordinating a post mortem needle biopsy study of lung pathology in fatal paediatric pneumonia.

 

Dengue Fever and Dengue Haemorrhagic Fever

With Dr Prida Malasit (Department of Medicine, Siriraj Hospital) we are examining the pathology of Dengue Virus infection

 

Group Members:

Dr Gareth Turner Head of Pathology, MORU and Honorary Consultant, Tropical Pathology. Honorary Senior Lecturer NDCLS, Oxford University

Assoc Prof Emsri Pongponrat Head of Department, Tropical Pathology

Asst Prof Urai Chaisri Deputy Head of Department, Tropical Pathology

Dr Panote Prapansilp Assistant Lecturer, Tropical Pathology and DPhil Student – Malaria Pathology, Nuffield Department of Medicine, University of Oxford

Dr Piyanate Sunyakumthorn (Post doc – Rickettsial immunopathogenesis)

Kemajittra Jenjaroen (MSc Student – Rickettsia)

Dr Sumate Ampawong (Post doc – Malaria Lung Pathology)

Sethawud Chaikigosiyakul (MSc Student – Placental Malaria)

 

Previous Group Members:

Dr Isabelle Medana

Dr Heidi Brown

Dr Navakanit Sachanonta

Dr Sudarat Nguansangiam

 

 

Sources of Funding:

 

The Wellcome Trust The Thrasher Research Fund, USA
John Fell Foundation, Oxford University The Bill & Melinda Gates Foundation
The Thailand Research Fund The Pathological Society of Great Britain

Estimation of gestational age from fundal height

Estimation of gestational age from fundal height: a solution for resource poor settings

Lisa J. White1,2, Sue J Lee1,2, Kasia Stepniewska1,2, Julie A. Simpson2,3, Saw Lu Mu Dwell4, Ratree Arunjerdja4, Pratap Singhasivanon2, Nicholas J. White1,2, Francois Nosten1,2,4, Rose McGready1,2,4

 

1Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK

2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia.

4Shoklo Malaria Research Unit, PO Box 46 Mae Sot, Tak, Thailand, 63110

 

Summary

Many women in resource poor settings lack access to reliable gestational age assessment because they do not know their last menstrual period (LMP), there is no ultrasound and methods of newborn gestational age dating are not practiced by birth attendants. A bespoke multiple-measures model was developed to predict the expected date of delivery (EDD) determined by ultrasound.   Prospectively collected early ultrasound and serial symphysis-pubis fundal height (SFH) data were used in the model. The data were collected from Karen and Burmese women attending antenatal care on the Thai-Burmese border. SFH remains the proxy for gestational age in much of the resource poor world. While more accurate measures should be encouraged we provide a formula that incorporates at least three SFH measures from an individual mother and the slopes between them provides a significant increase in the accuracy of prediction compared with linear and non-linear formulae also using multiple SFH measures.

 

Click here to download an excel file that will apply the model to SFH measures.

Click here to download more detailed information about this model.

Medicine Quality

There are severe but neglected problems with poor medicine quality globally, but especially for anti-infective medicines in the tropics. These have important but under-recognised impacts on public health. Poor quality drugs have clear importance for individual patients, in terms of death, treatment failure, prolonged sickness, excess health expenditure, and lost income. Poor quality drugs also have far reaching consequences for society, resulting in loss of confidence in efficacious medicines and health systems, and economic losses to patients, health systems, their employment, and the pharmaceutical industry.  We are conducting random sampling of medicines to objectively estimate the prevalence of counterfeit and sub-standard drugs, evaluating new rapid assessment techniques for medicine quality and advocating that much more is done to improve the quality of the medicine supply. We host the coordination for the new Anti-Malarial Quality module of WWARN (www.wwarn.org) to tabulate, map, disseminate and discuss global data on the quality of antimalarial medicines.