Scientific Achievements 2009-14


Since its inception, MORU has made major progress scientifically, institutionally, in building capacity and in translating research into policy and practice. We have delivered on our mission to improve public health and reduce the human disease burden in the developing world. For example it is estimated that three million deaths have been averted since 2001 as a result of improved malaria control – largely as a result of deployment of insecticide treated bed-nets and the artemisinin-based combination treatments (ACT) that were pioneered by our programme.

We have focused scientifically on our core research themes of malaria, clinical epidemiology and diagnostics, rickettsial infections, leptospirosis, melioidosis, sepsis, pharmacometrics and medicine quality, and worked closely with our sister MOP in Vietnam on intensive care medicine, malaria, tuberculosis, acute respiratory infections, enteric infections and dengue. To these ends together with the Vietnam MOP we have developed a uniquely flexible and capable network of research units and collaborations across the tropical world, with the aim of providing practical solutions to major health problems.

Since 2009, we have added four new substantial research sites to our network: the Cambodia-Oxford Medical Research Unit (COMRU) in Siem Reap, Cambodia, building on our existing successful collaboration with the Angkor Hospital for Children; the Myanmar-Oxford Clinical Research Unit (MOCRU) based in Yangon, which mainly conducts studies on artemisinin-resistant malaria; the Kinshasa Oxford Medical Research Unit (KIMORU) which focuses on the treatment of severe malaria and a clinical research site with laboratory facilities for the study of rickettsial infections and severe sepsis in Chiangrai in Northern Thailand. In addition many of the other research facilities and sites have been upgraded and enhanced.

The results of our research efforts have been disseminated through 702 scientific publications (as well as 41 books and book chapters) since March 2009. This represents over 40% of all journal articles published by the Unit in its 35 year history (Figure 1).