Pharmacology, run by Niklas Lindegardh (Department Head), is based in newly refurbished laboratories in the Faculty of Tropical Medicine, Bangkok. We specialise in bioanalysis of anti-infective drugs in biological fluids, and are one of the world’s leading laboratory for the measurement of antimalarial and anti-influenza drugs. A variety of sample preparation techniques (such as solid-phase extraction, liquid-liquid extraction) are combined with LC-MS, LC-MS/MS and LC-UV methodologies. All assays are developed and conducted to international guidelines and full ISO accreditation standards.

The laboratory has its own QA/QC sub-department, and inter-laboratory quality control and assurance schemes have been established. The samples come from a wide range of pharmacokinetic and pharmacodynamic studies conducted in collaboration with clinical departments within the Programme and with collaborators outside. The department conducts pharmacokinetic data analysis including non-compartmental modelling, and compartmental modelling on an individual and the population basis. They are supervising the development of the new pharmacology laboratory within the Viet Nam MOP in HCM City, and are active founding members of the wWARN (World Wide Antimalarial Resistance Network).

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